Easy, efficient, and economic synthesis of anilines remains an important challenge in
synthetic chemistry. In this study, a Ni (OAc) 2-bipyridine complex is shown to readily …

Drug metabolism is critical to many aspects of drug safety and efficacy. Thus, understanding
the various intricacies of drug metabolism helps to avoid possible pitfalls and contributes to …

Pyridine and its derivatives constitute the majority of heterocyclic aromatic compounds that
occur largely as a result of human activities and contribute to environmental pollution. It is …

A nitrogen replacement process that directly incorporates the 15N atom of glycine-15N into
anilines was reported. The process involves a Csp2–N bond cleavage of anilines driven by …

A simple and selective method for introducing stable 13 C and 15 N isotopes into the
structure of the sodium salt of 4-oxo-1, 4-dihydropyrazolo [5, 1-c][1, 2, 4] triazine-3, 8 …

In the past 20 years, several novel data-mining methods, inclining mass defect filtering,
background subtraction, isotope pattern filtering, and metabolomics analysis, have been …

Background: Significant under-prediction of in vivo clearance in rat was observed for a
potent p21-activated kinase (PAK1) inhibitor, GNE1. Objective: Rate-determining (rapid …

Synthesis, complex stability and small animal PET imaging of a novel 64 Cu-labelled cryptand
molecule - MedChemComm (RSC Publishing) DOI:10.1039/C4MD00174E Royal Society of …

The use of stable isotopes in drug metabolism studies and drug design are described here.
Stable isotopes have been reported as tracers and labels, which allow scientists to utilize a …

Разработан простой и селективный метод введения стабильных изотопов 13С и 15N в
структуру натриевой соли диэтилового эфира 4-оксо-1, 4-дигидропиразоло [5, 1-c][1, 2 …