Nitric oxide (NO) is a molecule with pleiotropic effects in different tissues. NO is synthesized
by NO synthases (NOS), a family with four major types: endothelial, neuronal, inducible and …

Background Cell-based strategies focusing on replacement or protection of dopaminergic
neurons have been considered as a potential approach to treat Parkinson's disease (PD) for …

Nitric oxide and other redox active molecules such as oxygen free radicals provide essential
signalling in diverse neuronal functions, but their excess production and insufficient …

Neurogenesis is known to occur in the specific niches of the adult mammalian brain, but
whether germinal centers exist in the neural-crest-derived peripheral nervous system is …

GDNF is a potent neurotrophic factor that protects catecholaminergic neurons from toxic
damage and induces fiber outgrowth. However, the actual role of endogenous GDNF in the …

Fetal nigral grafts have been demonstrated to survive, secrete dopamine, form synaptic
connections with host neurons, and reverse behavioral disturbances in experimental models …

Glial cell line‐derived neurotrophic factor (GDNF) mRNA is highly expressed by dental pulp
cells (DPCs) prior to the initiation of dental pulp innervation. We show that radioactively …

Cell therapy for Parkinson's disease (PD) began in 1979 with the transplantation of fetal rat
dopamine-containing neurons that improved motor abnormalities in the PD rat model with …

The carotid body (CB) is an arterial chemoreceptor organ located in the carotid bifurcation
and has a well-recognized role in cardiorespiratory regulation. The CB contains …

Parkinson's disease is a complex disorder characterized by degeneration of dopaminergic
neurons in the substantia nigra in the brain. Stem cell transplantation is aimed at replacing …