Arachidonic acid metabolism and kidney inflammation
As a major component of cell membrane lipids, Arachidonic acid (AA), being a major
component of the cell membrane lipid content, is mainly metabolized by three kinds of …
component of the cell membrane lipid content, is mainly metabolized by three kinds of …
Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome
Acute inflammatory responses are protective, yet without timely resolution can lead to
chronic inflammation and organ fibrosis. A systems approach to investigate self-limited (self …
chronic inflammation and organ fibrosis. A systems approach to investigate self-limited (self …
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation
Obesity induces chronic inflammation resulting in insulin resistance and metabolic
disorders. Cold exposure can improve insulin sensitivity in humans and rodents, but the …
disorders. Cold exposure can improve insulin sensitivity in humans and rodents, but the …
Resolvins and protectins in inflammation resolution
CN Serhan, NA Petasis - Chemical reviews, 2011 - ACS Publications
The critical role of inflammatory processes in health and disease has long been recognized,
1 yet the detailed molecular mechanisms and biological events that regulate the progression …
1 yet the detailed molecular mechanisms and biological events that regulate the progression …
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
JZ Haeggstrom, CD Funk - Chemical reviews, 2011 - ACS Publications
Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …
Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals
Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase
(COX)-2 enabling the biosynthesis of R-containing precursors of endogenous …
(COX)-2 enabling the biosynthesis of R-containing precursors of endogenous …
The lipoxygenase pathway
I Feussner, C Wasternack - Annual review of plant biology, 2002 - annualreviews.org
▪ Abstract Lipid peroxidation is common to all biological systems, both appearing in
developmentally and environmentally regulated processes of plants. The hydroperoxy …
developmentally and environmentally regulated processes of plants. The hydroperoxy …
Leukotrienes and lipoxins: structures, biosynthesis, and biological effects
B Samuelsson, SE Dahlen, JÅ Lindgren, CA Rouzer… - Science, 1987 - science.org
Arachidonic acid is released from membrane phospholipids upon cell stimulation (for
example, by immune complexes and calcium ionophores) and converted to leukotrienes by …
example, by immune complexes and calcium ionophores) and converted to leukotrienes by …
Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
M Spite, LV Norling, L Summers, R Yang, D Cooper… - Nature, 2009 - nature.com
A growing body of evidence indicates that resolution of acute inflammation is an active
process,. Resolvins are a new family of lipid mediators enzymatically generated within …
process,. Resolvins are a new family of lipid mediators enzymatically generated within …
Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation
T Shimizu - Annual review of pharmacology and toxicology, 2009 - annualreviews.org
Prostaglandins, leukotrienes, platelet-activating factor, lysophosphatidic acid, sphingosine 1-
phosphate, and endocannabinoids, collectively referred to as lipid mediators, play pivotal …
phosphate, and endocannabinoids, collectively referred to as lipid mediators, play pivotal …