A central goal in neuroscience is to determine how the brain's neuronal circuits generate
perception, cognition and emotions and how these lead to appropriate behavioural actions …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily affecting
cognitive functions. However, sensory deficits in AD start to draw attention due to their high …

For half a century now, the barrel cortex of common laboratory rodents has been an
exceptionally useful model for studying the formation of topographically organized maps …

Background Alzheimer's disease (AD) is generally thought to spare primary sensory
function; however, such interpretations have drawn from a literature that has rarely taken into …

Resting state (rs) fMRI allows measurement of brain functional connectivity and has
identified default mode (DMN) and task positive (TPN) network disruptions as promising …

Vascular changes are thought to contribute to the development of Alzheimer's disease, and
both cerebral blood flow and its responses during neural activation are reduced before …

Amyloid plaque–forming transgenic mice display neuronal hyperexcitability, epilepsy, and
sudden deaths in early adulthood. However, it is unknown whether hyperexcitability persists …

In Alzheimer's disease and related dementias, amyloid beta (Aβ) and amyloid plaques can
disrupt long-term synaptic plasticity, learning and memory and cognitive function. Plaque …

Early impairments to neurovascular coupling have been proposed to be a key pathogenic
factor in the onset and progression of Alzheimer's disease (AD). Studies have shown …

Active whisking in mice and rats is one of the fastest behaviours known in mammals and is
used to guide complex behaviours such as exploration and navigation. During object …