Mitochondrial CHCHD2: disease-associated mutations, physiological functions, and current animal models

TR Kee, P Espinoza Gonzalez, JL Wehinger… - Frontiers in aging …, 2021 - frontiersin.org
Rare mutations in the mitochondrial protein coiled-coil-helix-coiled-coil-helix domain
containing 2 (CHCHD2) are associated with Parkinson's disease (PD) and other Lewy body …

Pathogenesis of Parkinson's disease: from hints from monogenic familial PD to biomarkers

N Hattori, M Funayama, Y Imai, T Hatano - Journal of Neural Transmission, 2024 - Springer
Twenty-five years have passed since the causative gene for familial Parkinson's disease
(PD), Parkin (now PRKN), was identified in 1998; PRKN is the most common causative gene …

Mutations in CHCHD2 cause α-synuclein aggregation

A Ikeda, K Nishioka, H Meng… - Human molecular …, 2019 - academic.oup.com
Mutations in CHCHD2 are linked to a familial, autosomal dominant form of Parkinson's
disease (PD). The gene product may regulate mitochondrial respiratory function. However …

PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction

W Zhou, D Ma, AX Sun, HD Tran, D Ma… - Human molecular …, 2019 - academic.oup.com
Abstract Coiled-coil-helix-coiled-coil-helix domain containing protein 2 (CHCHD2) mutations
were linked with autosomal dominant Parkinson's disease (PD) and recently, Alzheimer's …

Neurodegeneration-associated mitochondrial proteins, CHCHD2 and CHCHD10–what distinguishes the two?

A Ikeda, Y Imai, N Hattori - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and Coiled-coil-helix-
coiled-coil-helix domain containing 10 (CHCHD10) are mitochondrial proteins that are …

Twin CHCH proteins, CHCHD2, and CHCHD10: key molecules of Parkinson's disease, amyotrophic lateral sclerosis, and frontotemporal dementia

Y Imai, H Meng, K Shiba-Fukushima… - International journal of …, 2019 - mdpi.com
Mutations of coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and 10
(CHCHD10) have been found to be linked to Parkinson's disease (PD), amyotrophic lateral …

Glutathione depletion and microRNA dysregulation in multiple system atrophy: a review

C Kinoshita, N Kubota, K Aoyama - International Journal of Molecular …, 2022 - mdpi.com
Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by
parkinsonism, cerebellar impairment, and autonomic failure. Although the causes of MSA …

Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson's Disease

M Suzuki, K Sango, Y Nagai - International Journal of Molecular Sciences, 2022 - mdpi.com
α-Synuclein (αSyn) plays a major role in the pathogenesis of Parkinson's disease (PD),
which is the second most common neurodegenerative disease after Alzheimer's disease …

Cross-examining candidate genes implicated in multiple system atrophy

JS Katzeff, K Phan, S Purushothuman… - Acta neuropathologica …, 2019 - Springer
Multiple system atrophy (MSA) is a devastating neurodegenerative disease characterized by
the clinical triad of parkinsonism, cerebellar ataxia and autonomic failure, impacting on …

Mitochondrial CHCHD2 and CHCHD10: roles in neurological diseases and therapeutic implications

W Zhou, D Ma, EK Tan - The Neuroscientist, 2020 - journals.sagepub.com
CHCHD2 mutations have been identified in various neurological diseases such as
Parkinson's disease (PD), frontotemporal dementia (FTD), and Alzheimer's disease (AD). It …