Cyclic adenosine monophosphate (cAMP) is the first discovered second messenger, which
plays pivotal roles in cell signaling, and regulates many physiological and pathological …

Androgen signaling is a critical determinant of timely and proper development of all male
organs including the prostate. Maturation of prostate and its neoplastic transformation is …

Adhesion G protein-coupled receptors are elusive in terms of their structural information and
ligands. Here, we solved the cryogenic-electron microscopy (cryo-EM) structure of apo …

The adhesion receptor ADGRA3 (GPR125) is a known spermatogonial stem cell marker, but
its impact on male reproduction and fertility has not been examined. Using a mouse model …

T helper 17 (Th17) cells subtype of non‐T2 asthma is less responsive (resistant) to inhaled
corticosteroids (ICS), so also called severe asthma. Methyl‐CpG‐binding domain protein 2 …

Human G protein‐coupled receptor 56 (GPR56) is encoded by gene ADGRG1 from
chromosome 16q21 and is homologously encoded in mice, at chromosome 8. Both 687 and …

GPR56, an adhesion G-protein coupled receptor (aGPCRs) with constitutive and ligand-
promoted activity, is involved in many physiological and pathological processes. Whether …

The activation of G Protein-Coupled Receptor 56 (GPR56), also referred to as Adhesion G-
Protein-Coupled Ceceptor G1 (ADGRG1), by Collagen Type III (Coll III) prompts cell growth …

Studies have shown that androgens can alleviate the symptoms of T2 asthma and are
inversely correlated with the severity of allergic asthma. METTL3, a crucial component of …

Prostate cancer (PCa) is the second most prevalent cancer in men. In 2020, approximately
1,414,259 new cases were reported that accounted for 3, 75,324 deaths (Sung et al. in CA …