Leishmania tarentolae: a vaccine platform to target dendritic cells and a surrogate pathogen for next generation vaccine research in leishmaniases and viral …

C Bandi, JA Mendoza-Roldan, D Otranto, A Alvaro… - Parasites & …, 2023 - Springer
Parasites of the genus Leishmania are unusual unicellular microorganisms in that they are
characterized by the capability to subvert in their favor the immune response of mammalian …

Leishmania tarentolae: A new frontier in the epidemiology and control of the leishmaniases

JA Mendoza‐Roldan, J Votýpka… - Transboundary and …, 2022 - Wiley Online Library
Leishmaniasis (or the leishmaniases), classified as a neglected tropical parasitic disease, is
found in parts of the tropics, subtropics and southern Europe. Leishmania parasites are …

[HTML][HTML] Efficacy of mucosal vaccination using a protozoan parasite as a vehicle for antigen delivery: IgG and neutralizing response after rectal administration of …

S Epis, I Varotto-Boccazzi, A Manenti, D Rubolini… - Pharmacological …, 2022 - Elsevier
Mucosal vaccination is regarded as a promising alternative to classical, intramuscular
vaccine delivery. However, only a limited number of vaccines have been licensed for …

Leishmania tarentolae as a platform for the production of vaccines against viral pathogens

M Zimna, E Krol - npj Vaccines, 2024 - nature.com
Infectious diseases remain a persistent public health problem and a leading cause of
morbidity and mortality in both humans and animals. The most effective method of …

Leishmania tarentolae as an Antigen Delivery Platform: Dendritic Cell Maturation after Infection with a Clone Engineered to Express the SARS-CoV-2 Spike Protein

I Varotto-Boccazzi, M Garziano, GM Cattaneo… - Vaccines, 2022 - mdpi.com
Background: Protozoa of the genus Leishmania are characterized by their capacity to target
macrophages and Dendritic Cells (DCs). These microorganisms could thus be exploited for …

A novel chemically defined medium for the biotechnological and biomedical exploitation of the cell factory Leishmania tarentolae

GM Cattaneo, I Varotto-Boccazzi, R Molteni… - Scientific Reports, 2024 - nature.com
The development of media for cell culture is a major issue in the biopharmaceutical industry,
for the production of therapeutics, immune-modulating molecules and protein antigens …

Serum antibody fingerprinting of SARS-CoV-2 variants in infected and vaccinated subjects by label-free microarray biosensor

T Carzaniga, L Casiraghi, G Nava, G Zanchetta… - Frontiers in …, 2024 - frontiersin.org
Both viral infection and vaccination affect the antibody repertoire of a person. Here, we
demonstrate that the analysis of serum antibodies generates information not only on the …

Regulating the product quality of COVID-19 antigen testing reagents: A tripartite evolutionary game analysis under China's legal framework

Z Huang, X Wang, Z Feng, B Chen - Frontiers in Public Health, 2023 - frontiersin.org
Personal purchases of novel coronavirus antigen detection reagents (ADRs) for self-
detection have contributed to the optimization of medical resources and containment of the …

Immunogenicity evaluation of next-generation vaccine platforms for prevention of Influenza and COVID-19

I Razzano - 2023 - usiena-air.unisi.it
Background: Over the past hundred years, humans have experienced a long list of microbial
threats to health. Among them, pandemics represent one of the major burdens for public …