Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

The ability of cells to sense and respond to mechanical signals is vital in development and
healthy tissue functioning. Many diseases are related to either changing mechanical …

Cell migration affects all morphogenetic processes and contributes to numerous diseases,
including cancer and cardiovascular disease. For most cells in most environments …

Mechanical forces are central to developmental, physiological and pathological processes.
However, limited understanding of force transmission within sub-cellular structures is a …

Recent progress in the design and application of artificial cellular microenvironments and
nanoenvironments has revealed the extraordinary ability of cells to adjust their cytoskeletal …

Cancer cells possess a broad spectrum of migration and invasion mechanisms. These
include both individual and collective cell-migration strategies. Cancer therapeutics that are …

Integrins bind extracellular matrix fibrils and associate with intracellular actin filaments
through a variety of cytoskeletal linker proteins to mechanically connect intracellular and …

Cell adhesions mediate important bidirectional interactions between cells and the
extracellular matrix. They provide an interactive interface between the extracellular chemical …

Interactions between cells and the extracellular matrix coordinate signaling pathways that
control various aspects of cellular behavior. Integrins sense the physical properties of the …