TMBserval: a statistical explainable learning model reveals weighted tumor mutation burden better categorizing therapeutic benefits
A high tumor mutation burden (TMB) is known to drive the response to immune checkpoint
inhibitors (ICI) and is associated with favorable prognoses. However, because it is a one …
inhibitors (ICI) and is associated with favorable prognoses. However, because it is a one …
TMBcat: A multi-endpoint p-value criterion on different discrepancy metrics for superiorly inferring tumor mutation burden thresholds
Tumor mutation burden (TMB) is a widely recognized stratification biomarker for predicting
the efficacy of immunotherapy; however, the number and universal definition of the …
the efficacy of immunotherapy; however, the number and universal definition of the …
Identification of the role of endoplasmic reticulum stress genes in endometrial cancer and their association with tumor immunity
T Zhang, Q Zhang, J Zhang, R Zhao, R Shi, S Wei… - BMC Medical …, 2023 - Springer
Background Endometrial cancer (EC) is one of the worldwide gynecological malignancies.
Endoplasmic reticulum (ER) stress is the cellular homeostasis disturbance that participates …
Endoplasmic reticulum (ER) stress is the cellular homeostasis disturbance that participates …
OCRFinder: a noise-tolerance machine learning method for accurately estimating open chromatin regions
J Ren, Y Liu, X Zhu, X Wang, Y Li, Y Liu, W Hu… - Frontiers in …, 2023 - frontiersin.org
Open chromatin regions are the genomic regions associated with basic cellular
physiological activities, while chromatin accessibility is reported to affect gene expressions …
physiological activities, while chromatin accessibility is reported to affect gene expressions …
TMBstable: a variant caller controls performance variation across heterogeneous sequencing samples
S Wang, X Zhu, X Wang, Y Liu, M Zhao… - Briefings in …, 2024 - academic.oup.com
In cancer genomics, variant calling has advanced, but traditional mean accuracy evaluations
are inadequate for biomarkers like tumor mutation burden, which vary significantly across …
are inadequate for biomarkers like tumor mutation burden, which vary significantly across …
An association between ATP7B expression and human cancer prognosis and immunotherapy: a pan-cancer perspective
Z Zhang, A Zhang, Y Shi, Z Zhao, Z Zhao - BMC Medical Genomics, 2023 - Springer
Background ATP7B is a copper-transporting protein that contributes to the chemo-resistance
of human cancer cells. It remains unclear what the molecular mechanisms behind ATP7B …
of human cancer cells. It remains unclear what the molecular mechanisms behind ATP7B …
CYP19A1 promotes gastric cancer as part of a lipid metabolism-related gene signature related to the response of immunotherapy and prognosis
X Zhou, F Meng, L Xiao, H Shen - BMC Medical Genomics, 2023 - Springer
Background Increasing evidence suggests that the metabolism of lipids plays a crucial role
in the progression of gastric cancer. However, the expression of lipid metabolism-related …
in the progression of gastric cancer. However, the expression of lipid metabolism-related …
A Statistical Explainable Learning Model Optimizing Co-localization of Multidimensional Positivity Thresholds in Immunotherapy Decision-Supporting
Y Wang, J Liu, J Zhao, J Wang… - … on Bioinformatics and …, 2023 - ieeexplore.ieee.org
Tumor Mutation Burden (TMB) serves as a recognized stratified biomarker for
immunotherapy. However, its one-dimensional representation of non-synonymous genetic …
immunotherapy. However, its one-dimensional representation of non-synonymous genetic …
SPAJoint: A Multivariate Saddlepoint Approximation for Time-to-Event and Response Joint Analysis
X Lai, M An, X Zhang, X Zhu, Y Liu, Y Shao, J Wang… - 2024 - researchsquare.com
Time-to-event and response endpoints are typical phenotypes in association studies that
often exhibit stochastic correlation within the same individual. However, current analytic …
often exhibit stochastic correlation within the same individual. However, current analytic …