Oxidatively induced DNA damage and its repair in cancer
M Dizdaroglu - Mutation Research/Reviews in Mutation Research, 2015 - Elsevier
Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …
Does measurement of oxidative damage to DNA have clinical significance?
Oxidative damage to DNA is the seemingly inevitable consequence of cellular metabolism.
Furthermore, despite protective mechanisms, cellular levels of damage may increase under …
Furthermore, despite protective mechanisms, cellular levels of damage may increase under …
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Cancers have dysfunctional redox regulation resulting in reactive oxygen species
production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized …
production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized …
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and
malignant disease. Cellular models of RAS-dependent cancers have been used to identify …
malignant disease. Cellular models of RAS-dependent cancers have been used to identify …
Oxidative guanine base damage regulates human telomerase activity
Abstract Changes in telomere length are associated with degenerative diseases and cancer.
Oxidative stress and DNA damage have been linked to both positive and negative …
Oxidative stress and DNA damage have been linked to both positive and negative …
Targeting DNA repair, DNA metabolism and replication stress as anti‐cancer strategies
Anti‐cancer therapies targeting and damaging the DNA have been extensively used in the
last 50 years since the discovery of nitrogen mustards, antimetabolites and platin agents …
last 50 years since the discovery of nitrogen mustards, antimetabolites and platin agents …
Mechanisms and consequences of cancer genome instability: lessons from genome sequencing studies
During tumor evolution, cancer cells can accumulate numerous genetic alterations, ranging
from single nucleotide mutations to whole-chromosomal changes. Although a great deal of …
from single nucleotide mutations to whole-chromosomal changes. Although a great deal of …
DNA oxidation: investigating its key role in environmental mutagenesis with the comet assay
A Azqueta, S Shaposhnikov, AR Collins - Mutation Research/Genetic …, 2009 - Elsevier
DNA oxidation, which can have potentially serious mutagenic consequences, commonly
accompanies exposure to environmental mutagens. Oxidised bases can be measured …
accompanies exposure to environmental mutagens. Oxidised bases can be measured …
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence
Reactive oxygen species (ROS) appear to play a role in limiting both cellular and organismic
lifespan. However, because of their pleiotropic effects, it has been difficult to ascribe a …
lifespan. However, because of their pleiotropic effects, it has been difficult to ascribe a …
Oxidized extracellular DNA as a stress signal in human cells
AV Ermakov, MS Konkova, SV Kostyuk… - Oxidative medicine …, 2013 - Wiley Online Library
The term “cell‐free DNA”(cfDNA) was recently coined for DNA fragments from
plasma/serum, while DNA present in in vitro cell culture media is known as extracellular …
plasma/serum, while DNA present in in vitro cell culture media is known as extracellular …