Dissolution of oncofusion transcription factor condensates for cancer therapy
Cancer-associated chromosomal rearrangements can result in the expression of numerous
pathogenic fusion proteins. The mechanisms by which fusion proteins contribute to …
pathogenic fusion proteins. The mechanisms by which fusion proteins contribute to …
Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer
Three-dimensional (3D) chromatin structure plays a critical role in development, gene
regulation, and cellular identity. Alterations to this structure can have profound effects on …
regulation, and cellular identity. Alterations to this structure can have profound effects on …
Clinically relevant fusion oncogenes: Detection and practical implications
M Sorokin, E Rabushko… - Therapeutic …, 2022 - journals.sagepub.com
Mechanistically, chimeric genes result from DNA rearrangements and include parts of
preexisting normal genes combined at the genomic junction site. Some rearranged genes …
preexisting normal genes combined at the genomic junction site. Some rearranged genes …
Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer
Metastatic relapse after treatment is the leading cause of cancer mortality, and known
resistance mechanisms are missing for most treatments administered to patients. To bridge …
resistance mechanisms are missing for most treatments administered to patients. To bridge …
Fusion gene map of acute leukemia revealed by transcriptome sequencing of a consecutive cohort of 1000 cases in a single center
X Chen, F Wang, Y Zhang, X Ma, P Cao, L Yuan… - Blood cancer …, 2021 - nature.com
Fusion genes (FGs) are important genetic abnormalities in acute leukemias, but their variety
and occurrence in acute leukemias remain to be systematically described. Whole …
and occurrence in acute leukemias remain to be systematically described. Whole …
FusionNeoAntigen: a resource of fusion gene-specific neoantigens
Among the diverse sources of neoantigens (ie single-nucleotide variants (SNVs), insertions
or deletions (Indels) and fusion genes), fusion gene-derived neoantigens are generally …
or deletions (Indels) and fusion genes), fusion gene-derived neoantigens are generally …
The landscape of chimeric RNAs in non-diseased tissues and cells
Chimeric RNAs and their encoded proteins have been traditionally viewed as unique
features of neoplasia, and have been used as biomarkers and therapeutic targets for …
features of neoplasia, and have been used as biomarkers and therapeutic targets for …
Whole transcriptome sequencing detects a large number of novel fusion transcripts in patients with AML and MDS
A Stengel, R Shahswar, T Haferlach, W Walter… - Blood …, 2020 - ashpublications.org
Fusion transcripts are frequent genetic abnormalities in myeloid malignancies and are often
the basis for risk stratification, minimal residual disease (MRD) monitoring, and targeted …
the basis for risk stratification, minimal residual disease (MRD) monitoring, and targeted …
The landscape of long noncoding RNA-involved and tumor-specific fusions across various cancers
The majority of the human genome encodes long noncoding RNA (lncRNA) genes, critical
regulators of various cellular processes, which largely outnumber protein-coding genes …
regulators of various cellular processes, which largely outnumber protein-coding genes …
Clinical application of whole transcriptome sequencing for the classification of patients with acute lymphoblastic leukemia
W Walter, R Shahswar, A Stengel, M Meggendorfer… - BMC cancer, 2021 - Springer
Background Considering the clinical and genetic characteristics, acute lymphoblastic
leukemia (ALL) is a rather heterogeneous hematological neoplasm for which current …
leukemia (ALL) is a rather heterogeneous hematological neoplasm for which current …