How adhesive interactions between cells generate and maintain animal tissue structure
remains one of the most challenging and long-standing questions in cell and developmental …

Despite decades of search for anticancer drugs targeting solid tumors, this group of
diseases remains largely incurable, especially if in advanced, metastatic stage. In this …

Synapse formation involves reciprocal interactions between cells resulting in formation of a
structure optimized for efficient information transfer. Recent work has implicated constituents …

Cadherin genes encode a superfamily of conserved transmembrane proteins that share an
adhesive ectodomain composed of tandem cadherin repeats. More than 100 human …

Abstract β-catenin is widely regarded as the primary transducer of canonical WNT signals to
the nucleus. In most vertebrates, there are eight additional catenins that are structurally …

Human embryonic stem cells (ESCs [hESCs]) proliferate as colonies wherein individual cells
are strongly adhered to one another. This architecture is linked to hESC self-renewal …

The arrival of multicellularity in evolution facilitated cell–cell signaling in conjunction with
adhesion. As the ectodomains of cadherins interact with each other directly in trans (as well …

Tumor invasion and metastasis are major obstacles to clinical treatment that rely on cell
migration. Here, we elucidate a mechanism of colon carcinoma cell migration that is …

Embryonic stem (ES) and induced-pluripotent stem (iPS) cells can be grown indefinitely
under appropriate conditions whilst retaining the ability to differentiate to cells representative …

Convergent extension (CE) is an evolutionarily conserved collective cell movement that
elongates several organ systems during development. Studies have revealed two distinct …