Circular RNA: metabolism, functions and interactions with proteins

WY Zhou, ZR Cai, J Liu, DS Wang, HQ Ju, RH Xu - Molecular cancer, 2020 - Springer
Abstract Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules
that are ubiquitous across species ranging from viruses to mammals. Important advances …

Targeting circular RNAs as a therapeutic approach: current strategies and challenges

AT He, J Liu, F Li, BB Yang - Signal transduction and targeted therapy, 2021 - nature.com
Significant progress has been made in circular RNA (circRNA) research in recent years.
Increasing evidence suggests that circRNAs play important roles in many cellular processes …

Circular RNAs in breast cancer diagnosis, treatment and prognosis

X Huang, C Song, J Zhang, L Zhu… - Oncology research, 2023 - pmc.ncbi.nlm.nih.gov
Breast cancer has surpassed lung cancer to become the most common malignancy
worldwide. The incidence rate and mortality rate of breast cancer continue to rise, which …

Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

C Cui, J Yang, X Li, D Liu, L Fu, X Wang - Molecular cancer, 2020 - Springer
Circular RNAs (circRNAs), one type of non-coding RNA, were initially misinterpreted as
nonfunctional products of pre-mRNA mis-splicing. Currently, circRNAs have been proven to …

CircRNAs: biogenesis, functions, and role in drug-resistant Tumours

S Ma, S Kong, F Wang, S Ju - Molecular cancer, 2020 - Springer
Targeted treatment, which can specifically kill tumour cells without affecting normal cells, is a
new approach for tumour therapy. However, tumour cells tend to acquire resistance to …

Breast cancer; discovery of novel diagnostic biomarkers, drug resistance, and therapeutic implications

S Afzal, M Hassan, S Ullah, H Abbas… - Frontiers in molecular …, 2022 - frontiersin.org
Breast cancer is the second most reported cancer in women with high mortality causing
millions of cancer-related deaths annually. Early detection of breast cancer intensifies the …

CircRNAs in anticancer drug resistance: recent advances and future potential

T Xu, M Wang, L Jiang, L Ma, L Wan, Q Chen, C Wei… - Molecular cancer, 2020 - Springer
CircRNAs are a novel class of RNA molecules with a unique closed continuous loop
structure. CircRNAs are abundant in eukaryotic cells, have unique stability and tissue …

Insights into the role of CircRNAs: biogenesis, characterization, functional, and clinical impact in human malignancies

S Nisar, AA Bhat, M Singh, T Karedath… - Frontiers in cell and …, 2021 - frontiersin.org
Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding
endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be …

Circular RNAs as potential biomarkers in breast cancer

FDE De Palma, F Salvatore, JG Pol, G Kroemer… - Biomedicines, 2022 - mdpi.com
Due to the high heterogeneity and initially asymptomatic nature of breast cancer (BC), the
management of this disease depends on imaging together with immunohistochemical and …

The circular RNA circSKA3 binds integrin β1 to induce invadopodium formation enhancing breast cancer invasion

WW Du, W Yang, X Li, L Fang, N Wu, F Li, Y Chen… - Molecular therapy, 2020 - cell.com
Metastatic cancer cells invade surrounding tissues by forming dynamic actin-based
invadopodia, which degrade the surrounding extracellular matrix and allow cancer cell …