The CXC chemokine CXCL12 is an important factor in physiological and pathological
processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation …

Dipeptidyl-peptidase IV/CD26 (DPP IV) is a cell-surface protease belonging to the
prolyloligopeptidase family. It selectively removes the N-terminal dipeptide from peptides …

Granulocyte colony-stimulating factor (G-CSF)–induced hematopoietic stem cell mobilization
is widely used for clinical transplantation; however, the mechanism is poorly understood. We …

Dipeptidyl-peptidase IV (DPP IV/CD26) has a dual function as a regulatory protease and as
a binding protein. Its role in the inactivation of bioactive peptides was recognized 20 years …

Background CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is
phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and …

Chemokines, or chemotactic cytokines, and their receptors have been discovered as
essential and selective mediators in leukocyte migration to inflammatory sites and to …

Chemokines, small pro-inflammatory chemoattractant cytokines, that bind to specific G-
protein-coupled seven-span transmembrane receptors present on plasma membranes of …

CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic
chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis …

Proteases function at every level in host defense, from regulating vascular hemostasis and
inflammation to mobilizing the" rapid responder" leukocytes of the immune system by …

CD26/DPPIV can be considered a moonlighting protein because it is a multifunctional
protein that exerts its different functions depending on cell type and intra-or extracellular …