In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

Autophagy fights against harmful stimuli and degrades cytosolic macromolecules,
organelles, and intracellular pathogens. Autophagy dysfunction is associated with many …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Modifications of epigenetic factors affect our lives and can give important information
regarding one's state of health. In cancer, epigenetic modifications play a crucial role, as …

Patients with diabetes are more vulnerable to myocardial ischemia/reperfusion (MI/R) injury,
which is associated with excessive reactive oxygen species (ROS) generation and …

Pyroptosis is a new necrosis pattern of hepatocyte during liver inflammation in acute liver
failure (ALF). Histone deacetylase 2 (HDAC2) is associated with several pathological …

Abstract Sequestosome 1 (SQSTM1)/p62 is an adapter protein mainly involved in the
transportation, degradation and destruction of various proteins that cooperates with …

Mitophagy plays a critical role in regulating and maintaining cellular functions, particularly
regulating the quantity and quality of mitochondria. In this research, a multifunctional two …

Tumor suppressor p53 can transcriptionally activate downstream genes in response to
stress, and then regulate the cell cycle, DNA repair, metabolism, angiogenesis, apoptosis …

Background P62 (also named sequestosome‐1, SQSTM1) is involved in autophagy
regulation through multiple pathways. It interacts with autophagosomes‐associated LC3‐II …