Abstract Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), a component of
Gram-negative bacteria to induce production of pro-inflammatory mediators aiming at …

Three originally distinct concepts–lipid rafts, detergent-resistant membranes (DRMs) and
liquid-ordered (lo) lipid phases–are often confused in current literature; many researchers …

The biological membrane is a complicated matrix wherein different lipid environments are
thought to exist. The more ordered or raft environment has been perceived biochemically …

Eukaryotic cell membranes contain microdomains called lipid rafts, which are cholesterol-
rich domains in which lipid acyl chains are tightly packed and highly extended. A variety of …

Abstract Phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2] is a minor lipid of the inner
leaflet of the plasma membrane that controls the activity of numerous proteins and serves as …

The original 'lipid raft'hypothesis proposed that lipid‐platforms/rafts form in the exoplasmic
plasmalemmal leaflet by tight clustering of sphingolipids and cholesterol. Their physical …

Lipid rafts, defined as cholesterol-and sphingolipid-rich domains, provide specialized lipid
environments understood to regulate the organization and function of many plasma …

Despite the role of sphingolipid/cholesterol rafts as signaling platforms for Fcγ receptor II
(FcγRII), the mechanism governing translocation of an activated receptor toward the rafts is …

The serine-threonine kinase, Akt1/protein kinase Bα is an important mediator of growth,
survival, and metabolic signaling. Recent studies have implicated cholesterol-rich, lipid raft …

Many immunoreceptors have been reported to associate with lipid rafts upon ligand binding.
The way in which this association is regulated is still obscure. We investigated the roles for …