The amyloid cascade hypothesis: an updated critical review

KP Kepp, NK Robakis, PF Høilund-Carlsen, SL Sensi… - Brain, 2023 - academic.oup.com
Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

Lifestyle modulators of neuroplasticity: how physical activity, mental engagement, and diet promote cognitive health during aging

C Phillips - Neural plasticity, 2017 - Wiley Online Library
The number of the elderly across the globe will approximate 2.1 billion by 2050. Juxtaposed
against this burgeoning segment of the population is evidence that nonpathological aging is …

Association of body mass index with risk of cognitive impairment and dementia: a systematic review and meta-analysis of prospective studies

Y Qu, HY Hu, YN Ou, XN Shen, W Xu, ZT Wang… - Neuroscience & …, 2020 - Elsevier
Controversies persist about the associations of body mass index (BMI) with risk of cognitive
impairment and dementia. This study aimed to evaluate these associations from various …

Long-term high-fat diet consumption by mice throughout adulthood induces neurobehavioral alterations and hippocampal neuronal remodeling accompanied by …

H Zhuang, X Yao, H Li, Q Li, C Yang, C Wang… - Brain, behavior, and …, 2022 - Elsevier
High-fat diet (HFD) consumption is generally associated with an increased risk of cognitive
and emotional dysfunctions that constitute a sizeable worldwide health burden with …

Obesity reduces cognitive and motor functions across the lifespan

C Wang, JSY Chan, L Ren, JH Yan - Neural plasticity, 2016 - Wiley Online Library
Due to a sedentary lifestyle, more and more people are becoming obese nowadays. In
addition to health‐related problems, obesity can also impair cognition and motor …

Overfed but undernourished: recognizing nutritional inadequacies/deficiencies in patients with overweight or obesity

A Astrup, S Bügel - International journal of obesity, 2019 - nature.com
Overweight and obesity are highly prevalent throughout the world and can adversely affect
the nutritional status of individuals. Studies have shown that many people with obesity have …

Obesity-induced cognitive impairment in older adults: a microvascular perspective

P Balasubramanian, T Kiss… - American Journal …, 2021 - journals.physiology.org
Over two-thirds of individuals aged 65 and older are obese or overweight in the United
States. Epidemiological data show an association between the degree of adiposity and …

N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer's disease mouse model

S Suzzi, T Croese, A Ravid, O Gold, AR Clark… - Nature …, 2023 - nature.com
Systemic immunity supports lifelong brain function. Obesity posits a chronic burden on
systemic immunity. Independently, obesity was shown as a risk factor for Alzheimer's …

Inflammation and insulin resistance as risk factors and potential therapeutic targets for Alzheimer's disease

A Vinuesa, C Pomilio, A Gregosa… - Frontiers in …, 2021 - frontiersin.org
Overnutrition and modern diets containing high proportions of saturated fat are among the
major factors contributing to a low-grade state of inflammation, hyperglycemia and …

Body mass index and decline of cognitive function

S Kim, Y Kim, SM Park - PLOS one, 2016 - journals.plos.org
Background The association between body mass index (BMI) and cognitive function is a
public health issue. This study investigated the relationship between obesity and cognitive …