A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Generating new life in animals by sexual reproduction depends on adequate
communication between mature and competent male and female gametes. Ion channels are …

Fertilization occurs after the completion of the sperm acrosome reaction, a secretory event
that is triggered during gamete adhesion. ZP3, an egg zona pellucida glycoprotein …

Ion channels and transporters, key elements in sperm–egg signaling and environmental
sensing, are essential for fertilization. External cues and components from the outer …

As sperm prepare for fertilization, surface Ca 2+ channels must open to initiate required, Ca
2+-mediated events. However, the molecular identity and functional properties of sperm Ca …

Ca2+ is a ubiquitous intracellular messenger which encodes information by temporal and
spatial patterns of concentration. In spermatozoa, several key functions, including acrosome …

The past 5 years has witnessed an advance in our understanding of alpha1G (Ca v 3.1),
alpha1H (Ca v 3.2), and alpha1l (Ca v 3.3), the pore-forming subunits of T-type or low …

We used mice with targeted deletion of 25-hydroxyvitamin D-1 α-hydroxylase [1α (OH)
ase−/−] to investigate whether 1, 25 (OH) 2D3 deficiency results in male infertility mediated …

To fertilize, mammalian sperm must complete a maturational process called capacitation. It
is thought that the membrane potential of sperm hyperpolarizes during capacitation, possibly …

Sperm chemotaxis, which guide sperm toward oocyte, is tightly associated with sperm
capacitation, motility, and fertility. However, the molecular mechanism of sperm chemotaxis …