Solvent-free melting techniques for the preparation of lipid-based solid oral formulations

K Becker, S Salar-Behzadi, A Zimmer - Pharmaceutical Research, 2015 - Springer
Lipid excipients are applied for numerous purposes such as taste masking, controlled
release, improvement of swallowability and moisture protection. Several melting techniques …

Hot-melt coating with lipid excipients

V Jannin, Y Cuppok - International journal of pharmaceutics, 2013 - Elsevier
Polymer coatings are widely used to provide drug protection, taste masking, coloration and
modified drug release. Typically, coating polymers must be diluted or dispersed in solvents …

[HTML][HTML] Designing optimal formulations for hot-melt coating

DG Lopes, S Salar-Behzadi, A Zimmer - International journal of …, 2017 - Elsevier
Hot-melt coating (HMC) as a solvent-free technology grants faster and more economic
coating processes with reduced risk of dissolving the drug during the process. Moreover …

Experimental investigation of process stability of continuous spray fluidized bed layering with external product separation

M Schmidt, C Rieck, A Bück, E Tsotsas - Chemical Engineering Science, 2015 - Elsevier
The present work investigates experimentally continuous spray fluidized bed layering with
external product separation. In this process configuration, growing particles are continuously …

Experimental investigation of process stability of continuous spray fluidized bed layering with internal separation

M Schmidt, A Bück, E Tsotsas - Chemical Engineering Science, 2015 - Elsevier
The present work investigates spray fluidized bed layering to continuously generate sodium
benzoate granules from a solution. Product granules are discharged from the process …

Role of lipid blooming and crystallite size in the performance of highly soluble drug-loaded microcapsules

DG Lopes, K Becker, M Stehr, D Lochmann… - Journal of …, 2015 - Elsevier
Hot-melt coating is of growing interest, because it does not require solvents, resulting in
reduced process times and costs. However, excipients for this technology are mainly …

On the properties and application of beeswax, carnauba wax and palm fat mixtures for hot melt coating in fluidized beds

MG Müller, JA Lindner, H Briesen, K Sommer… - Advanced Powder …, 2018 - Elsevier
Coating of particulate solids is a well-known process within the chemical, pharmaceutical
and food industry. Most of these industries use it to achieve a defined product behavior. Melt …

Preparation and evaluation of metoprolol tartrate sustained-release pellets using hot melt extrusion combined with hot melt coating

Y Yang, L Shen, J Li, W Shan - Drug Development and Industrial …, 2017 - Taylor & Francis
The objective of this study was to prepare and evaluate metoprolol tartrate sustained-
release pellets. Cores were prepared by hot melt extrusion and coated pellets were …

A solids mixing rate correlation for small scale fluidized beds

S Gorji-Kandi, SM Alavi-Amleshi, N Mostoufi - Particuology, 2015 - Elsevier
A new first degree solids mixing rate is proposed to evaluate the mixing of solids in small
scale fluidized beds. Particle mixing experiments were carried out in a 2D fluidized bed with …

Effect of plasma irradiation on the fine particle behavior in a spouted bed

B Zhang, N Kobayashi, Y Itaya - Powder Technology, 2019 - Elsevier
The combination of a spouted bed with non-thermal plasma has been used widely in
industrial chemical processes. However, the detailed behavior of particles in a spouted bed …