Functional dental pulp regeneration: basic research and clinical translation

Z Xie, Z Shen, P Zhan, J Yang, Q Huang… - International journal of …, 2021 - mdpi.com
Pulpal and periapical diseases account for a large proportion of dental visits, the current
treatments for which are root canal therapy (RCT) and pulp revascularisation. Despite the …

Cells and material-based strategies for regenerative endodontics

Z Siddiqui, AM Acevedo-Jake, A Griffith… - Bioactive Materials, 2022 - Elsevier
The carious process leads to inflammation of pulp tissue. Current care options include root
canal treatment or apexification. These procedures, however, result in the loss of tooth …

Dental stem cell dynamics in periodontal ligament regeneration: from mechanism to application

S Wen, X Zheng, W Yin, Y Liu, R Wang, Y Zhao… - Stem Cell Research & …, 2024 - Springer
Periodontitis, a globally prevalent chronic inflammatory disease is characterized by the
progressive degradation of tooth-supporting structures, particularly the periodontal ligament …

Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine

Y Chen, H Huang, G Li, J Yu, F Fang, W Qiu - Stem Cell Research & …, 2022 - Springer
Stem cells transplantation is the main method of tissue engineering regeneration treatment,
the viability and therapeutic efficiency are limited. Scaffold materials also play an important …

A review of in vivo and clinical studies applying scaffolds and cell sheet technology for periodontal ligament regeneration

M Bousnaki, A Beketova, E Kontonasaki - Biomolecules, 2022 - mdpi.com
Different approaches to develop engineered scaffolds for periodontal tissues regeneration
have been proposed. In this review, innovations in stem cell technology and scaffolds …

Can vitamins improve periodontal wound healing/regeneration?

KM Fawzy El‐Sayed, R Cosgarea… - Periodontology …, 2024 - Wiley Online Library
Periodontitis is a complex inflammatory disorder of the tooth supporting structures,
associated with microbial dysbiosis, and linked to a number if systemic conditions. Untreated …

Therapeutic potential of dental pulp stem cells according to different transplant types

T Staniowski, A Zawadzka-Knefel… - Molecules, 2021 - mdpi.com
Stem cells are unspecialised cells capable of perpetual self-renewal, proliferation and
differentiation into more specialised daughter cells. They are present in many tissues and …

Efficient bone regeneration of BMP9-stimulated human periodontal ligament stem cells (hPDLSCs) in decellularized bone matrix (DBM) constructs to model …

Y Zhang, W Luo, L Zheng, J Hu, L Nie, H Zeng… - Stem Cell Research & …, 2022 - Springer
Abstract Background BMP9-stimulated DPSCs, SCAPs and PDLSCs are effective
candidates for repairing maxillofacial bone defects in tissue engineering, while the most …

Recent advancements in hydrogels as novel tissue engineering scaffolds for dental pulp regeneration

X Guo, J Li, Y Wu, L Xu - International Journal of Biological Macromolecules, 2024 - Elsevier
Although conventional root canal treatment offers an effective therapeutic solution, it
negatively affects the viability of the affected tooth. In recent years, pulp regeneration …

[HTML][HTML] Carbon dots enhance extracellular matrix secretion for dentin-pulp complex regeneration through PI3K/Akt/mTOR pathway-mediated activation of autophagy

L Liu, X Li, W Bu, N Jin, Y Meng, Y Wang, D Wang… - Materials Today Bio, 2022 - Elsevier
Pulp injury is one of the most common clinical diseases, and severe cases are usually
associated with the functional loss of the tooth, while the current clinical treatment modality is …