Glycogen synthase kinase-3 inhibitors: preclinical and clinical focus on CNS-A decade onward
SM Arciniegas Ruiz, H Eldar-Finkelman - Frontiers in molecular …, 2022 - frontiersin.org
The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …
recognized a promising drug discovery target in treating multiple pathological conditions …
Cyclin-dependent kinase-like 5 deficiency disorder: clinical review
HE Olson, ST Demarest, EM Pestana-Knight… - Pediatric …, 2019 - Elsevier
Abstract Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a
developmental encephalopathy caused by pathogenic variants in the gene CDKL5. This …
developmental encephalopathy caused by pathogenic variants in the gene CDKL5. This …
Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy
PD Negraes, CA Trujillo, NK Yu, W Wu, H Yao… - Molecular …, 2021 - nature.com
Early-onset epileptic encephalopathies are severe disorders often associated with specific
genetic mutations. In this context, the CDKL5 deficiency disorder (CDD) is a …
genetic mutations. In this context, the CDKL5 deficiency disorder (CDD) is a …
CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility
K Okuda, S Kobayashi, M Fukaya, A Watanabe… - Neurobiology of …, 2017 - Elsevier
Mutations in the Cyclin-dependent kinase-like 5 (CDKL5) gene cause severe
neurodevelopmental disorders accompanied by intractable epilepsies, ie West syndrome or …
neurodevelopmental disorders accompanied by intractable epilepsies, ie West syndrome or …
A subset of autism-associated genes regulate the structural stability of neurons
YC Lin, JA Frei, MBC Kilander, W Shen… - Frontiers in cellular …, 2016 - frontiersin.org
Autism spectrum disorder (ASD) comprises a range of neurological conditions that affect
individuals' ability to communicate and interact with others. People with ASD often exhibit …
individuals' ability to communicate and interact with others. People with ASD often exhibit …
Molecular and synaptic bases of CDKL5 disorder
YC Zhu, ZQ Xiong - Developmental Neurobiology, 2019 - Wiley Online Library
The X‐linked gene cyclin‐dependent kinase‐like 5 (CDKL5) encodes a serine/threonine
kinase abundantly expressed in the brain. Mutations in CDKL5 have been associated with …
kinase abundantly expressed in the brain. Mutations in CDKL5 have been associated with …
CDKL5 deficiency disorder: molecular insights and mechanisms of pathogenicity to fast-track therapeutic development
NJ Van Bergen, S Massey, A Quigley… - Biochemical Society …, 2022 - portlandpress.com
CDKL5 deficiency disorder (CDD) is an X-linked brain disorder of young children and is
caused by pathogenic variants in the cyclin-dependent kinase-like 5 (CDKL5) gene …
caused by pathogenic variants in the cyclin-dependent kinase-like 5 (CDKL5) gene …
HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder
S Trazzi, C Fuchs, R Viggiano… - Human molecular …, 2016 - academic.oup.com
Abstract Cyclin-dependent kinase-like 5 (CDKL5) is a Ser/Thr protein kinase predominantly
expressed in the brain. Mutations of the CDKL5 gene lead to CDKL5 disorder, a …
expressed in the brain. Mutations of the CDKL5 gene lead to CDKL5 disorder, a …
Loss of CDKL5 in glutamatergic neurons disrupts hippocampal microcircuitry and leads to memory impairment in mice
Cyclin-dependent kinase-like 5 (CDKL5) deficiency is a neurodevelopmental disorder
characterized by epileptic seizures, severe intellectual disability, and autistic features. Mice …
characterized by epileptic seizures, severe intellectual disability, and autistic features. Mice …
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 …
A Castano, M Silvestre, CI Wells, JL Sanderson… - Elife, 2023 - elifesciences.org
Pathological loss-of-function mutations in cyclin-dependent kinase-like 5 (CDKL5) cause
CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental disorder …
CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental disorder …