Over the last decade, single-cell genomics has revealed remarkable heterogeneity and
plasticity of cell types in the lungs and airways. The challenge now is to understand how …

Hedgehog (Hh) signaling is a well-established developmental pathway; it is crucial for early
embryogenesis, cell differentiation, and damage-driven regeneration. It is being increasingly …

Epigallocatechin gallate (EGCG) is a polyphenol plant metabolite abundant in tea that has
demonstrated antifibrotic properties in the lung. In this issue of the JCI, Cohen, Brumwell …

Our previous work demonstrated the anti-fibrotic effects of infusion of adipose-derived
mesenchymal stem cells (ASCs) to prevent or repair bleomycin-induced lung injury. The …

Background Glycolysis plays a major role in progression of idiopathic pulmonary fibrosis
(IPF). Here, we aim to explore the predictive signature based on glycolysis-related genes for …

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by repetitive
alveolar injuries with excessive deposition of extracellular matrix (ECM) proteins. A crucial …

The respiratory system, including the lungs, is essential for terrestrial life. While recent
research has advanced our understanding of lung development, much still relies on animal …

Aging is a multifactorial and complex physiological process, affecting every organ with
characteristic manifestations. Understanding the molecular mechanisms that drive aging …

Spatial transcriptomics (ST) has the potential to provide unprecedented insights into gene
expression across tissue architecture, but existing analytical methods often overlook the full …

The gain-of-function MUC5B promoter variant is the dominant risk factor for the development
of idiopathic pulmonary fibrosis (IPF). However, its impact on protein expression in both non …