Biomechanics of the optic nerve head

IA Sigal, CR Ethier - Experimental eye research, 2009 - Elsevier
Biomechanical factors acting at the level of the lamina cribrosa (LC) are postulated to play a
role in retinal ganglion cell dysfunction and loss in glaucoma. In support of this postulate, we …

Premise and prediction—how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head

CF Burgoyne, JC Downs - Journal of glaucoma, 2008 - journals.lww.com
We propose that age-related alterations in optic nerve head (ONH) biomechanics underlie
the clinical behavior and increased susceptibility of the aged ONH to glaucomatous …

Factors influencing optic nerve head biomechanics

IA Sigal, JG Flanagan, CR Ethier - … ophthalmology & visual …, 2005 - iovs.arvojournals.org
purpose. The biomechanical environment within the optic nerve head (ONH) may play a role
in retinal ganglion cell loss in glaucomatous optic neuropathy. This was a systematic …

[HTML][HTML] Corneal hysteresis but not corneal thickness correlates with optic nerve surface compliance in glaucoma patients

AP Wells, DF Garway-Heath, A Poostchi… - … & visual science, 2008 - arvojournals.org
purpose. To investigate relationships between acute intraocular pressure (IOP)–induced
optic nerve head surface deformation and corneal hysteresis and thickness in glaucomatous …

3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: lamina cribrosa and peripapillary scleral position and thickness

H Yang, JC Downs, C Girkin, L Sakata… - … & visual science, 2007 - iovs.arvojournals.org
purpose. To delineate three-dimensionally the anterior and posterior surfaces of the lamina
cribrosa, scleral flange, and peripapillary sclera, to determine the position and thickness of …

IOP-induced lamina cribrosa displacement and scleral canal expansion: an analysis of factor interactions using parameterized eye-specific models

IA Sigal, H Yang, MD Roberts… - … & visual science, 2011 - iovs.arvojournals.org
Purpose.: To study the anterior–posterior lamina cribrosa deformation (LCD) and the scleral
canal expansion (SCE) produced by an increase in IOP and identify the main factors and …

Modeling individual-specific human optic nerve head biomechanics. Part I: IOP-induced deformations and influence of geometry

IA Sigal, JG Flanagan, I Tertinegg, CR Ethier - Biomechanics and modeling …, 2009 - Springer
Glaucoma, the second most common cause of blindness worldwide, is an ocular disease
characterized by progressive loss of retinal ganglion cell (RGC) axons. Biomechanical …

Predicted extension, compression and shearing of optic nerve head tissues

IA Sigal, JG Flanagan, I Tertinegg, CR Ethier - Experimental eye research, 2007 - Elsevier
Glaucomatous optic neuropathy may be in part due to an altered biomechanical
environment within the optic nerve head (ONH) produced by an elevated intraocular …

Eye-specific IOP-induced displacements and deformations of human lamina cribrosa

IA Sigal, JL Grimm, NJ Jan, K Reid… - … & visual science, 2014 - iovs.arvojournals.org
Purpose.: To measure high-resolution eye-specific displacements and deformations induced
within the human LC microstructure by an acute increase in IOP. Methods.: Six eyes from …

Lamina cribrosa and peripapillary sclera histomorphometry in normal and advanced glaucomatous Chinese eyes with various axial length

R Ren, N Wang, B Li, L Li, F Gao… - … & visual science, 2009 - iovs.arvojournals.org
purpose. To measure laminar and peripapillary scleral architecture in normal and
glaucomatous Chinese eyes with normal and those with elongated axial length. methods …