[HTML][HTML] Hyperpolarised benchtop NMR spectroscopy for analytical applications

AIS Terra, DA Taylor, ME Halse - Progress in Nuclear Magnetic Resonance …, 2024 - Elsevier
Benchtop NMR spectrometers, with moderate magnetic field strengths (B 0= 1− 2. 4 T) and
sub-ppm chemical shift resolution, are an affordable and portable alternative to standard …

Yeast Solutions and Hyperpolarization Enable Real-Time Observation of Metabolized Substrates Even at Natural Abundance

JP Peters, C Assaf, FH Mohamad, E Beitz… - Analytical …, 2024 - ACS Publications
Metabolic changes in an organism often occur much earlier than macroscopic
manifestations of disease, such as invasive tumors. Therefore, noninvasive tools to monitor …

Rescaling NMR for a Larger Deployment in Drug Discovery: Hyperpolarization and Benchtop NMR as Potential Game‐Changers

M Bütikofer, GR Stadler, F Torres - Chemistry‐Methods, 2024 - Wiley Online Library
Nuclear magnetic resonance (NMR) is recognized as the gold standard method in fragment‐
based drug design for screening, hit validation, and affinity determination. However, its …

Rapid in situ carbon-13 hyperpolarization and imaging of acetate and pyruvate esters without external polarizer

O Mohiuddin, H de Maissin, AN Pravdivtsev… - Communications …, 2024 - nature.com
Hyperpolarized 13C MRI visualizes real-time metabolic processes in vivo. In this study, we
achieved high 13C polarization in situ in the bore of an MRI system for precursor molecules …

Molecules, Up Your Spins!

DA Barskiy - Molecules, 2024 - mdpi.com
Nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI)
are indispensable tools in science and medicine, offering insights into the functions of …

Homogeneous Catalysts for Hydrogenative PHIP Used in Biomedical Applications

MT Huynh, Z Kovacs - Analysis & Sensing - Wiley Online Library
At present, two competing hyperpolarization (HP) techniques, dissolution dynamic nuclear
polarization (DNP) and parahydrogen (para‐H2) induced polarization (PHIP), can generate …