Biomaterials to mimic and heal connective tissues
BR Freedman, DJ Mooney - Advanced Materials, 2019 - Wiley Online Library
Connective tissue is one of the four major types of animal tissue and plays essential roles
throughout the human body. Genetic factors, aging, and trauma all contribute to connective …
throughout the human body. Genetic factors, aging, and trauma all contribute to connective …
[HTML][HTML] Recent developments in hyaluronic acid-based hydrogels for cartilage tissue engineering applications
Articular cartilage lesions resulting from injurious impact, recurring loading, joint
malalignment, etc., are very common and encompass the risk of evolving to serious cartilage …
malalignment, etc., are very common and encompass the risk of evolving to serious cartilage …
Bioactive factors for cartilage repair and regeneration: improving delivery, retention, and activity
Articular cartilage is a remarkable tissue whose sophisticated composition and architecture
allow it to withstand complex stresses within the joint. Once injured, cartilage lacks the …
allow it to withstand complex stresses within the joint. Once injured, cartilage lacks the …
Nanofibrous hyaluronic acid scaffolds delivering TGF-β3 and SDF-1α for articular cartilage repair in a large animal model
Focal cartilage injuries have poor intrinsic healing potential and often progress to
osteoarthritis, a costly disease affecting almost a third of adults in the United States. To treat …
osteoarthritis, a costly disease affecting almost a third of adults in the United States. To treat …
Stem cells for cartilage repair: preclinical studies and insights in translational animal models and outcome measures
M Lo Monaco, G Merckx, J Ratajczak… - Stem Cells …, 2018 - Wiley Online Library
Due to the restricted intrinsic capacity of resident chondrocytes to regenerate the lost
cartilage postinjury, stem cell‐based therapies have been proposed as a novel therapeutic …
cartilage postinjury, stem cell‐based therapies have been proposed as a novel therapeutic …
Within or without you? A perspective comparing in situ and ex situ tissue engineering strategies for articular cartilage repair
Human articular cartilage has a poor ability to self‐repair, meaning small injuries often lead
to osteoarthritis, a painful and debilitating condition which is a major contributor to the global …
to osteoarthritis, a painful and debilitating condition which is a major contributor to the global …
Mechanically Activated Microcapsules for “On‐Demand” Drug Delivery in Dynamically Loaded Musculoskeletal Tissues
Delivery of biofactors in a precise and controlled fashion remains a clinical challenge.
Stimuli‐responsive delivery systems can facilitate “on‐demand” release of therapeutics in …
Stimuli‐responsive delivery systems can facilitate “on‐demand” release of therapeutics in …
Rise of the pigs: utilization of the porcine model to study musculoskeletal biomechanics and tissue engineering during skeletal growth
Large animal models play an essential role in the study of tissue engineering and
regenerative medicine (TERM), as well as biomechanics. The porcine model has been …
regenerative medicine (TERM), as well as biomechanics. The porcine model has been …
Transection of the medial meniscus anterior horn results in cartilage degeneration and meniscus remodeling in a large animal model
The meniscus plays a central load‐bearing role in the knee joint. Unfortunately, meniscus
injury is common and can lead to joint degeneration and osteoarthritis (OA). In small animal …
injury is common and can lead to joint degeneration and osteoarthritis (OA). In small animal …
Mesenchymal stromal cells for articular cartilage repair: preclinical studies
P Fernández-Pernas, L Barrachina… - European Cells and …, 2020 - ruc.udc.es
Rheumatic diseases such as osteoarthritis (OA) are a major social and economic burden
because of the population aging and the lack of curative solutions. An effective cell therapy …
because of the population aging and the lack of curative solutions. An effective cell therapy …