Phenolic composition, antioxidant potential and health benefits of citrus peel

B Singh, JP Singh, A Kaur, N Singh - Food Research International, 2020 - Elsevier
Citrus peel (CP) forms around 40–50% of the total fruit mass but is generally thought to be a
waste. However, it is a substantial source of naturally occurring health enhancing …

Potential benefits of nobiletin, a citrus flavonoid, against Alzheimer's disease and Parkinson's disease

A Nakajima, Y Ohizumi - International journal of molecular sciences, 2019 - mdpi.com
Alzheimer's disease (AD), which is characterized by the presence of amyloid-β (Aβ) plaques
and neurofibrillary tangles, accompanied by neurodegeneration, is the most common form of …

Flavonoids as therapeutic agents in Alzheimer's and Parkinson's diseases: a systematic review of preclinical evidences

RB de Andrade Teles, TC Diniz… - Oxidative medicine …, 2018 - Wiley Online Library
Alzheimer's and Parkinson's diseases are considered the most common neurodegenerative
disorders, representing a major focus of neuroscience research to understanding the …

The impact of fruit flavonoids on memory and cognition

JPE Spencer - British Journal of Nutrition, 2010 - cambridge.org
There is intense interest in the studies related to the potential of phytochemical-rich foods to
prevent age-related neurodegeneration and cognitive decline. Recent evidence has …

Chemical structures, bioactivities and molecular mechanisms of citrus polymethoxyflavones

Z Gao, W Gao, SL Zeng, P Li, EH Liu - Journal of Functional Foods, 2018 - Elsevier
Citrus polymethoxyflavones (PMFs) and hydroxylated PMFs demonstrate potent bioactivities
in regulating cytoactivity and organ function by modulating signaling cascade, gene …

Natural polyphenols in the management of major depression

L Pathak, Y Agrawal, A Dhir - Expert opinion on investigational …, 2013 - Taylor & Francis
Introduction: Natural polyphenols, the non-essential micronutrients, found in array of plant
products, are known to affect various physiological and biochemical functions in the body …

Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain

JPE Spencer - Proceedings of the Nutrition Society, 2010 - cambridge.org
The consumption of flavonoid-rich foods and beverages has been suggested to limit the
neurodegeneration associated with a variety of neurological disorders and to prevent or …

Targeting autophagy and neuroinflammation pathways with plant‐derived natural compounds as potential antidepressant agents

T Mokhtari - Phytotherapy Research, 2022 - Wiley Online Library
Major depressive disorder (MDD) is a life‐threatening disease that presents several
characteristics. The pathogenesis of depression still remains poorly understood. Moreover …

Nobiletin inhibits CD36-dependent tumor angiogenesis, migration, invasion, and sphere formation through the Cd36/Stat3/Nf-Κb signaling axis

N Sp, DY Kang, DH Kim, JH Park, HG Lee, HJ Kim… - Nutrients, 2018 - mdpi.com
Targeted cancer therapy with natural compounds is more effective than nontargeted therapy.
Nobiletin is a flavonoid derived from citrus peel that has anticancer activity. Cluster of …

Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice

Y Yabuki, Y Ohizumi, A Yokosuka, Y Mimaki… - Neuroscience, 2014 - Elsevier
Nobiletin, a polymethoxylated flavonoid found in citrus fruit peel, reportedly improves
memory impairment in rodent models. Here we report its effect on 1-methyl-4-phenyl-1, 2, 3 …