Aldo–keto reductases comprise of AKR1C1–AKR1C4, four enzymes that catalyze NADPH
dependent reductions and have been implicated in biosynthesis, intermediary metabolism …

Old age is accompanied by a number of pathological eye conditions. Cataract is the most
common age-related eye complication. Because the lens becomes naturally more opaque …

Cataract is one of the earliest secondary complications of diabetes mellitus. The lens is a
closed system with limited capability to repair or regenerate itself. Current evidence supports …

Aldose reductase is an important enzyme in the polyol pathway, where glucose is converted
to fructose, and sorbitol is released. Aldose reductase activity increases in diabetes as the …

In continuation of our previous efforts directed towards the development of potent and
selective inhibitors of aldose reductase (ALR2), and to control the diabetes mellitus (DM), a …

Inhibitors of advanced glycation end-products formation and aldose reductase have been
considered to be potential treatment of diabetic complications. This study investigated the …

Aldose Reductase 2 (ALR2), the rate-limiting enzyme of the polyol pathway, plays an
important role in detoxification of some toxic aldehydes. Under hyperglycemia, this enzyme …

Xanthohumol (XN), a prenylated chalcone unique to hops (Humulus lupulus) and two
derived prenylflavanones, isoxanthohumol (IX) and 8-prenylnaringenin (8-PN) gained …

Diabetes-associated complications are a major global health concern. In diabetics, the
increased accumulation of sorbitol, produced via over activated polyol pathway, from …

Recent efforts to develop cure for chronic diabetic complications have led to the discovery of
potent inhibitors against aldose reductase (AKR1B1, EC 1.1. 1.21) whose role in diabetes is …