Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …

The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …

Simple Summary Through their regulatory effects on gene expression, histone
acetyltransferases have been implicated in the normal physiological activities and genesis …

Abstract Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of
hematologic malignancies, particularly pediatric leukemias with poor patient outcomes …

Overexpression of MYC is a hallmark of many human cancers. The MYC oncogene has long
been thought to execute its neoplastic functions by acting as a classic transcription factor …

p300 acts as a transcription coactivator and an acetyltransferase that plays an important role
in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is …

Aberrant gene expression is a hallmark of acute leukemias. MYB-driven transcriptional
coactivation with CREB-binding protein (CBP)/P300 is required for acute lymphoblastic and …

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease that
has a poor prognosis. Recent advances in genomics and molecular biology have led to a …

Epigenetic regulators are the largest group of genes mutated in MDS patients. Most mutated
genes belong to one of three groups of genes with normal functions in DNA methylation, in …

Dysregulated gene expression contributes to most prevalent features in human cancers.
Here, we show that most subtypes of acute myeloid leukemia (AML) depend on the aberrant …