Production and physiological effects of hydrogen sulfide

H Kimura - Antioxidants & redox signaling, 2014 - liebertpub.com
Abstract Significance: Hydrogen sulfide (H2S) has been recognized as a physiological
mediator with a variety of functions. It regulates synaptic transmission, vascular tone …

Forensic implications of genetic analyses from degraded DNA—a review

R Alaeddini, SJ Walsh, A Abbas - Forensic science international: genetics, 2010 - Elsevier
Forensic DNA identification techniques are principally based on determination of the size or
sequence of desired PCR products. The fragmentation of DNA templates or the structural …

Apoptotic cell death regulation in neurons

E Hollville, SE Romero, M Deshmukh - The FEBS journal, 2019 - Wiley Online Library
Apoptosis plays a major role in shaping the developing nervous system during
embryogenesis as neuronal precursors differentiate to become post‐mitotic neurons …

Programmed cell death in neurodevelopment

Y Yamaguchi, M Miura - Developmental cell, 2015 - cell.com
Programmed cell death (PCD) is an evolutionarily conserved contributor to nervous system
development. In the vertebrate peripheral nervous system, PCD is the basis of the …

Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration

A Wenzel, C Grimm, M Samardzija, CE Remé - Progress in retinal and eye …, 2005 - Elsevier
Human retinal dystrophies and degenerations and light-induced retinal degenerations in
animal models are sharing an important feature: visual cell death by apoptosis. Studying …

Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis

G Trichonas, Y Murakami, A Thanos… - Proceedings of the …, 2010 - National Acad Sciences
Apoptosis has been shown to be a significant form of cell loss in many diseases.
Detachment of photoreceptors from the retinal pigment epithelium, as seen in various retinal …

Cellular mechanisms of hereditary photoreceptor degeneration–Focus on cGMP

M Power, S Das, K Schütze, V Marigo, P Ekström… - Progress in Retinal and …, 2020 - Elsevier
The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …

Photoreceptor cell death and rescue in retinal detachment and degenerations

Y Murakami, S Notomi, T Hisatomi, T Nakazawa… - Progress in retinal and …, 2013 - Elsevier
Photoreceptor cell death is the ultimate cause of vision loss in various retinal disorders,
including retinal detachment (RD). Photoreceptor cell death has been thought to occur …

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

MS Gorbatyuk, T Knox, MM LaVail… - Proceedings of the …, 2010 - National Acad Sciences
The P23H mutation within the rhodopsin gene (RHO) causes rhodopsin misfolding,
endoplasmic reticulum (ER) stress, and activates the unfolded protein response (UPR) …

Mature neurons: equipped for survival

AJ Kole, RP Annis, M Deshmukh - Cell death & disease, 2013 - nature.com
Neurons completely transform how they regulate cell death over the course of their lifetimes.
Developing neurons freely activate cell death pathways to fine-tune the number of neurons …