Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

Filopodia are long, slender, actin-rich cellular protrusions, which recently have become a
focus of cell biology research because of their proposed roles as sensory and exploratory …

Members of the protein superfamily of small guanosine triphosphatases, also known as
small GTPases, small G-proteins, or the Ras superfamily, are involved in nearly every aspect …

The Arp2/3 complex nucleates actin filaments to generate networks at the leading edge of
motile cells. Nonmuscle myosin II produces contractile forces involved in driving actin …

Ciliogenesis requires the removal of CP110 from the mother centriole; actin dynamics also
influence ciliation, at least partly by affecting the centrosomal accumulation of ciliogenic …

The emergence of axonal filopodia is the first step in the formation of axon collateral
branches. In vitro, axonal filopodia emerge from precursor cytoskeletal structures termed …

The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal
processes during development. In the past two decades, great progress has been made in …

Cell migration is necessary for several developmental processes in multicellular organisms.
Furthermore, many physiological processes such as wound healing and immunological …

The WAVE regulatory complex (WRC), composed of five components—Cyfip1/Sra1,
WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300—is essential for proper actin …

Filopodia are finger-like cellular protrusions found throughout the metazoan kingdom and
perform fundamental cellular functions during development and cell migration. Neurons …