The so-called xenobiotic receptors (XRs) have functionally evolved into cellular sensors for
both endogenous and exogenous stimuli by regulating the transcription of genes encoding …

Endocrine-disrupting chemicals (EDCs) are exogenous substances interfering with hormone
biosynthesis, metabolism, or action, and consequently causing disturbances in the …

Wear is a familiar tribological failure in liquid lubrication, especially for low-viscosity base
oils without any additives. Therefore, it is necessary to understand and evaluate the anti …

Environmental toxicology has been expanding as growing concerns on the impact of
produced and released chemical compounds over the environment and human health are …

The mammalian circadian clock drives daily oscillations in physiology and behavior through
an autoregulatory transcription feedback loop present in central and peripheral cells …

Being in the center of both therapeutic and toxicological concerns, NRs are widely studied
for drug discovery application but also to unravel the potential toxicity of environmental …

The pregnane X receptor (PXR, NR1I2) is a nuclear receptor which exerts its regulatory
function by heterodimerization with the retinoid-X-receptor α (RXRα, NR2B1) and binding to …

Nuclear receptors are ligand-inducible transcriptional factors that control multiple biological
phenomena, including proliferation, differentiation, reproduction, metabolism, and the …

Microbial metabolite mimicry is a new concept that promises to deliver compounds that have
minimal liabilities and enhanced therapeutic effects in a host. In a previous publication, we …

Activation of pregnane X receptor (PXR) results in the induction of first-pass metabolism and
drug efflux. Hereby, PXR may cause adverse drug reactions or therapeutic failure of drugs …