Abstract Serotonin (5-HT) is a neurotransmitter found throughout the human body that
regulates many physiological events arising from the brain and central nervous system …

A series of pyrazolyl-s-triazine compounds with an indole motif was designed, synthesized,
and evaluated for anticancer activity targeting dual EGFR and CDK-2 inhibitors. The …

Serotonin 5-HT7 receptor (5-HT7R), one of the most recently discovered members of the
serotonergic system, has become a promising target in the search for central nervous …

Considering the key functions of the 5-HT7 receptor, especially in psychiatry, and the fact
that effective and selective 5-HT7 receptor ligands are yet to be available, in this work, we …

Owing to their multifunctional pharmacological profiles (including dual 5-HT 1A/5-HT 7
action), arylpiperazine derivatives are widely used for treating central nervous system …

Amphetamine derivatives negatively impact serotonin (5-HT) production, which triggers
apoptosis in different tissues, depending on the receptor they bind. 5-HT in the ovary …

Simple Summary Most patients with pancreatic cancer initially respond to the first-choice
drug gemcitabine, but the cancer cells rapidly acquire drug resistance, resulting in poor …

Prostate cancer (PC) is a clinically and biologically heterogeneous disease that lacks
effective treatment. Heat shock protein B8 (HSPB8) is an important factor in the progression …

Background Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer
and associated with poor prognosis and shorter survival due to significant genetic …

In this study, the concept of combined in vitro and in silico studies were utilized by using
some synthesized nitro bearing compounds. The anticancer activities of the studied …