Shikimate and phenylalanine biosynthesis in the green lineage
T Tohge, M Watanabe, R Hoefgen… - Frontiers in plant …, 2013 - frontiersin.org
The shikimate pathway provides carbon skeletons for the aromatic amino acids l-tryptophan,
l-phenylalanine, and l-tyrosine. It is a high flux bearing pathway and it has been estimated …
l-phenylalanine, and l-tyrosine. It is a high flux bearing pathway and it has been estimated …
Engineering cyanobacteria to generate high-value products
Although many microorganisms have been used for the bioindustrial generation of valuable
metabolites, the productive potential of cyanobacterial species has remained largely …
metabolites, the productive potential of cyanobacterial species has remained largely …
Modular (de) construction of complex bacterial phenotypes by CRISPR/nCas9-assisted, multiplex cytidine base-editing
CRISPR/Cas technologies constitute a powerful tool for genome engineering, yet their use
in non-traditional bacteria depends on host factors or exogenous recombinases, which limits …
in non-traditional bacteria depends on host factors or exogenous recombinases, which limits …
The entry reaction of the plant shikimate pathway is subjected to highly complex metabolite-mediated regulation
R Yokoyama, MVV de Oliveira, B Kleven… - The Plant …, 2021 - academic.oup.com
The plant shikimate pathway directs bulk carbon flow toward biosynthesis of aromatic amino
acids (AAAs, ie tyrosine, phenylalanine, and tryptophan) and numerous aromatic …
acids (AAAs, ie tyrosine, phenylalanine, and tryptophan) and numerous aromatic …
Engineering Escherichia coli to overproduce aromatic amino acids and derived compounds
The production of aromatic amino acids using fermentation processes with recombinant
microorganisms can be an advantageous approach to reach their global demands. In …
microorganisms can be an advantageous approach to reach their global demands. In …
Metabolic engineering of Escherichia coli: a sustainable industrial platform for bio-based chemical production
In order to decrease carbon emissions and negative environmental impacts of various
pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the …
pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the …
DCEO biotechnology: tools to design, construct, evaluate, and optimize the metabolic pathway for biosynthesis of chemicals
Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …
scale, but some drawbacks still exist in this process, such as unstable intermediates …
Styrene biosynthesis from glucose by engineered E. coli
R McKenna, DR Nielsen - Metabolic engineering, 2011 - Elsevier
Styrene is a large volume, commodity petrochemical with diverse commercial applications,
including as a monomer building-block for the synthesis of many useful polymers. Here we …
including as a monomer building-block for the synthesis of many useful polymers. Here we …
An optimization framework for identifying reaction activation/inhibition or elimination candidates for overproduction in microbial systems
P Pharkya, CD Maranas - Metabolic engineering, 2006 - Elsevier
We introduce a computational framework termed OptReg that determines the optimal
reaction activations/inhibitions and eliminations for targeted biochemical production. A …
reaction activations/inhibitions and eliminations for targeted biochemical production. A …
Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy
Flavonoids are valuable natural products widely used in human health and nutrition. Recent
advances in synthetic biology and metabolic engineering have yielded improved strain titers …
advances in synthetic biology and metabolic engineering have yielded improved strain titers …