The role of capsid in HIV-1 nuclear entry
A Guedán, ER Caroe, GCR Barr, KN Bishop - Viruses, 2021 - mdpi.com
HIV-1 can infect non-dividing cells. The nuclear envelope therefore represents a barrier that
HIV-1 must traverse in order to gain access to the host cell chromatin for integration. Hence …
HIV-1 must traverse in order to gain access to the host cell chromatin for integration. Hence …
HIV-1 capsid and viral DNA integration
The human immunodeficiency virus type 1 (HIV-1) genome encodes 15 proteins that
perform structural, enzymatic, regulatory, and accessory functions. The capsid protein (CA) …
perform structural, enzymatic, regulatory, and accessory functions. The capsid protein (CA) …
HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification and flanking linker …
ABSTRACT HIV-1 DNA is preferentially integrated into chromosomal hot spots by the
preintegration complex (PIC). To understand the mechanism, we measured the DNA …
preintegration complex (PIC). To understand the mechanism, we measured the DNA …
Cyclophilin A facilitates HIV-1 integration
A Padron, R Dwivedi, R Chakraborty… - Journal of …, 2024 - journals.asm.org
Cyclophilin A (CypA) binds to the HIV-1 capsid to facilitate reverse transcription and nuclear
entry and counter the antiviral activity of TRIM5α. Interestingly, recent studies suggest that …
entry and counter the antiviral activity of TRIM5α. Interestingly, recent studies suggest that …
HIV-1 mutants that escape the cytotoxic T-lymphocytes are defective in viral DNA integration
HIV-1 replication is durably controlled without antiretroviral therapy (ART) in certain infected
individuals called elite controllers (ECs). These individuals express specific human …
individuals called elite controllers (ECs). These individuals express specific human …
Human three prime repair exonuclease 1 promotes HIV-1 integration by preferentially degrading unprocessed viral DNA
Three prime repair exonuclease 1 (TREX1) is the most abundant 3′→ 5′ exonuclease in
mammalian cells. It has been suggested that TREX1 degrades HIV-1 DNA to enable the …
mammalian cells. It has been suggested that TREX1 degrades HIV-1 DNA to enable the …
Cyclophilin A Facilitates HIV-1 DNA Integration
A Padron, R Dwivedi, R Chakraborty, P Prakash, K Kim… - bioRxiv, 2024 - biorxiv.org
Cyclophilin A (CypA) promotes HIV-1 infection by facilitating reverse transcription, nuclear
entry and by countering the antiviral activity of TRIM5alpha. These multifunctional roles of …
entry and by countering the antiviral activity of TRIM5alpha. These multifunctional roles of …
[HTML][HTML] The chromatin binding domain, including the QPQRYG motif, of feline foamy virus Gag is required for viral DNA integration and nuclear accumulation of Gag …
The retroviral Gag protein, the major component of released particles, plays different roles in
particle assembly, maturation or infection of new host cells. Here, we characterize the Gag …
particle assembly, maturation or infection of new host cells. Here, we characterize the Gag …
[PDF][PDF] HIV-1 Preintegration Complex Preferentially Integrates the Viral DNA into Nucleosomes Containing Trimethylated Histone 3-Lysine 36 Modification and …
D Christensen, M Li, J Linderberger, M Kvaratskhelia… - 2022 - researchgate.net
ABSTRACT HIV-1 DNA is preferentially integrated into chromosomal hot spots by the
preintegration complex (PIC). To understand the mechanism, we measured the DNA …
preintegration complex (PIC). To understand the mechanism, we measured the DNA …
Mechanisms of Epigenetic Reader Proteins Interacting with Chromatin
KL Cox - 2024 - search.proquest.com
DNA is compacted in the eukaryotic cell nucleus into chromatin by wrapping~ 147 bp of
DNA at a time around protein histone octamer cores composed of 2 each of histones H2A …
DNA at a time around protein histone octamer cores composed of 2 each of histones H2A …