Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an
important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage …

Osteoarthritis (OA) is the most common musculoskeletal disease, affecting millions of
individuals worldwide. New treatment approaches require an understanding of the …

Aging is a main risk factor for osteoarthritis (OA). FoxO transcription factors protect against
cellular and organismal aging, and FoxO expression in cartilage is reduced with aging and …

The purpose of this study was to investigate the influence of moderate physical activity
(MPA) on the expression of osteoarthritis (OA)-related (IL-1β, IL-6, TNF-α, MMP-13) and anti …

Osteoarthritis is a complex disease involving the mechanical breakdown of articular
cartilage in the presence of altered joint mechanics and chondrocyte death, but the …

Abstract Background Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted
by synovial fibroblasts and superficial zone chondrocytes. PRG4 has a homeostatic …

Objective To evaluate the binding of recombinant human proteoglycan 4 (rhPRG4) to CD44
receptor and its consequences on cytokine‐induced synoviocyte proliferation. Methods The …

Mediterranean diet includes a relatively high fat consumption mostly from monounsaturated
fatty acids mainly provided by olive oil, the principal source of culinary and dressing fat. The …

Osteoarthritis (OA) is a common musculoskeletal disorder characterized by slow progression
and joint tissue degeneration. Aging is one of the most prominent risk factors for the …

Osteoarthritis is the most common human arthritis characterized by degeneration of articular
cartilage. Several studies reported that levels of human cartilage glycoprotein chitinase 3 …