T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …

T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …

T cell development in the mouse thymus has been studied extensively, but less is known
regarding T cell development in the human thymus. We used a combination of single-cell …

The intraepithelial lymphocytes (IELs) that reside within the epithelium of the intestine form
one of the main branches of the immune system. As IELs are located at this critical interface …

The ability to generate T cells from pluripotent stem cells (PSCs) has the potential to
transform autologous T cell immunotherapy by facilitating universal, off-the-shelf cell …

T cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy
driven mainly by oncogenic activation of NOTCH1 signaling. In this study we report the …

How chromatin reorganization coordinates differentiation and lineage commitment from
hematopoietic stem and progenitor cells (HSPCs) to mature immune cells has not been well …

Positive selection occurs in the thymic cortex, but critical maturation events occur later in the
medulla. Here we defined the precise stage at which T cells acquired competence to …

T cells develop in the thymus and are critical for adaptive immunity. Natural killer (NK)
lymphocytes constitute an essential component of the innate immune system in tumor …