Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

Abstract Background New Approach Methodologies (NAMs) comprise in silico and in vitro
methods applied as alternative to animal testing. Even though NAMs are already fully …

This Guidance document describes harmonised risk assessment methodologies for
combined exposure to multiple chemicals for all relevant areas within EFSA's remit, ie …

Benzotriazole ultraviolet stabilizers (BUVSs) are high-production-volume chemicals with
ubiquitous occurrence in the aquatic environment. However, little is known about their …

Glycogen phosphorylase (PG) is a key enzyme taking part in the first step of glycogenolysis.
Muscle glycogen phosphorylase (PYGM) differs from other PG isoforms in expression …

Since its creation in 2002, the European Food Safety Authority (EFSA) has produced risk
assessments for over 5000 substances in> 2000 Scientific Opinions, Statements and …

A wide diversity of plant protection products (PPP) is used for crop protection leading to the
contamination of soil, water, and air, which can have ecotoxicological impacts on living …

Simple Summary The identification and development of new anti-cancer drugs requires
extensive testing in animal models to establish safety and efficacy of drug candidates. The …

An increasing number of pharmaceuticals found in the environment potentially impose
adverse effects on organisms such as fish. Physiologically based kinetic (PBK) models are …

Bisphenol A (BPA) is an industrial chemical, which has raised human health and
environmental concerns due to its endocrine-disrupting properties. BPA analogues are less …