The 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme is vital for cellular
homeostasis due to its key functions in the one-carbon cycle, which include methionine and …

Background Globally, the prevalence of diabetes mellitus is increasing at an alarming rate.
This chronic pathology gravely troubled the human health and quality of life. Both insulin …

Although the association between maternal periconceptional diet and adult offspring health
is well characterised, our understanding of the impact of paternal nutrition at the time of …

Single-nucleotide polymorphisms within intron 1 of the FTO (fat mass and obesity-
associated) gene are associated with enhanced FTO expression, increased body weight …

Diabetic kidney disease (DKD) is a severe microvascular complication in patients with
diabetes and is one of the main causes of renal failure. The current clinical treatment …

Objective Fat mass and obesity-associated protein (FTO) is identified as a critical
demethylase involved in various physiological processes. Despite efforts have been made …

Introduction. Diabetes mellitus as the most prevalent metabolic disease is a multifactorial
disease which is influenced by environmental and genetic factors. In this systematic review …

Background DNA methylation is an epigenetic mechanism for regulating the transcription of
many genes and has been linked to the development of various diseases. A promising gene …

Abstract Combining a Sodium-Glucose-Cotransporter-2-inhibitor (SGLT2i) with metformin is
recommended for managing hyperglycemia in patients with type 2 diabetes (T2D) who have …

Early developmental environment can influence long-term health through reprogramming of
the epigenome. Human environmental epigenetics studies rely on surrogate tissues, such …