Synthesis of heterocycles via electrophilic cyclization of alkynes containing heteroatom

B Godoi, RF Schumacher, G Zeni - Chemical Reviews, 2011 - ACS Publications
The interest in synthesizing heterocycles has always been enormous. The literature contains
a variety of synthetic approaches to the heterocycle ring structures, much of which has been …

Bioactive Benzofuran derivatives: A review

H Khanam - European journal of medicinal chemistry, 2015 - Elsevier
In nature's collection of biologically active heterocycles, benzofuran derivatives constitute a
major group. The broad spectrum of pharmacological activity in individual benzofurans …

Recent updates on development of protein-tyrosine phosphatase 1B inhibitors for treatment of diabetes, obesity and related disorders

S Singh, AS Grewal, R Grover, N Sharma, B Chopra… - Bioorganic …, 2022 - Elsevier
The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …

Total synthesis of natural products containing benzofuran rings

MM Heravi, V Zadsirjan, H Hamidi, PHT Amiri - RSC advances, 2017 - pubs.rsc.org
Research on natural products containing benzofuran has remarkably increased during the
past few decades. Newly isolated natural products with complex structures are being …

Iodine-mediated synthesis of heterocycles via electrophilic cyclization of alkynes

T Aggarwal, S Kumar, AK Verma - Organic & biomolecular chemistry, 2016 - pubs.rsc.org
Iodine has been recognized as an efficient, non-toxic, readily available and easy-to-handle
electrophilic reagent to favour halocyclization reactions for the synthesis of novel …

Benzofuran derivatives: a patent review

KM Dawood - Expert opinion on therapeutic patents, 2013 - Taylor & Francis
Introduction: Benzofuran moiety constitutes the core of several interesting pharmacologically
active natural products. Benzofurans are among feasible potent active inhibitors against …

Electrophilic Cyclization of 2-Chalcogenealkynylanisoles: Versatile Access to 2-Chalcogen-benzo[b]furans

F Manarin, JA Roehrs, RM Gay… - The Journal of …, 2009 - ACS Publications
An efficient synthesis of 2-chalcogen-3-substituted-benzo [b] furan compounds has been
accomplished via electrophilic cyclization reaction of 2-chalcogenealkynyl anisoles using I2 …

Design, synthesis, biological evaluation, and molecular modeling studies of pyrazole-benzofuran hybrids as new α-glucosidase inhibitor

F Azimi, H Azizian, M Najafi, G Khodarahmi… - Scientific Reports, 2021 - nature.com
In this work, new derivatives of biphenyl pyrazole-benzofuran hybrids were designed,
synthesized and evaluated in vitro through enzymatic assay for inhibitory effect against α …

Recent and emerging anti‐diabetes targets

ML Mohler, Y He, Z Wu, DJ Hwang… - Medicinal research …, 2009 - Wiley Online Library
Diabetes is a disease that affects over 150 million people worldwide for which there are
multiple oral and injectable medications. Because of trends in obesity and sedentary …

Drug discovery and protein tyrosine phosphatases

MAT Blaskovich - Current medicinal chemistry, 2009 - ingentaconnect.com
Protein tyrosine phosphatases (PTPs) play a critical role in physiological signaling pathways
by controlling the level of tyrosine phosphorylation. The past decade has seen a vast …