Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …
Metabolic orchestration of the wound healing response
SA Eming, PJ Murray, EJ Pearce - Cell metabolism, 2021 - cell.com
Wound healing requires cooperation between different cell types, among which
macrophages play a central role. In particular, inflammatory macrophages are engaged in …
macrophages play a central role. In particular, inflammatory macrophages are engaged in …
Obesity, hypertension, and cardiac dysfunction: novel roles of immunometabolism in macrophage activation and inflammation
AJ Mouton, X Li, ME Hall, JE Hall - Circulation research, 2020 - Am Heart Assoc
Obesity and hypertension, which often coexist, are major risk factors for heart failure and are
characterized by chronic, low-grade inflammation, which promotes adverse cardiac …
characterized by chronic, low-grade inflammation, which promotes adverse cardiac …
ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection
S Cadenas - Free Radical Biology and Medicine, 2018 - Elsevier
Ischemia-reperfusion (IR) injury is central to the pathology of major cardiovascular diseases,
such as stroke and myocardial infarction. IR injury is mediated by several factors including …
such as stroke and myocardial infarction. IR injury is mediated by several factors including …
HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron
Hypoxia is a hallmark of solid tumors that promotes cell growth, survival, and metastasis and
confers resistance to chemo and radiotherapies. Hypoxic responses are largely mediated by …
confers resistance to chemo and radiotherapies. Hypoxic responses are largely mediated by …
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and
then restored, and underlies many disorders, notably heart attack and stroke. While …
then restored, and underlies many disorders, notably heart attack and stroke. While …
Nrf2 at the heart of oxidative stress and cardiac protection
QM Chen, AJ Maltagliati - Physiological genomics, 2018 - journals.physiology.org
The NFE2L2 gene encodes the transcription factor Nrf2 best known for regulating the
expression of antioxidant and detoxification genes. Gene knockout approaches have …
expression of antioxidant and detoxification genes. Gene knockout approaches have …
A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury
Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted—
ischemia—and then restored—reperfusion—leading to a burst of reactive oxygen species …
ischemia—and then restored—reperfusion—leading to a burst of reactive oxygen species …
Redox signaling by reactive electrophiles and oxidants
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …