Cancer cells exist in a complex ecosystem with numerous other cell types in the tumor
microenvironment (TME). The composition of this tumor/TME ecosystem will vary at each …

NF-Y is a conserved sequence-specific trimeric Transcription Factor-TF-binding to the
CCAAT element. We review here the role (s) in development, from pre-implantation embryo …

Currently, the dynamic accessible elements that determine regulatory programs responsible
for the unique identity and function of each cell type during zebrafish embryogenesis lack …

In anamniote embryos, the major wave of zygotic genome activation starts during the mid-
blastula transition. However, some genes escape global genome repression, are activated …

Transcriptional regulation is commonly governed by alternative promoters. However, the
regulatory architecture in alternative and reference promoters, and how they differ, remains …

The 5′ UTRs of mRNAs are critical for translation regulation during development, but their
in vivo regulatory features are poorly characterized. Here, we report the regulatory …

The zebrafish is amenable to a variety of genetic approaches. However, lack of conditional
deletion alleles limits stage-or cell-specific gene knockout. Here, we applied an existing …

Organogenesis is a highly complex and precisely regulated process. Here we profiled the
chromatin accessibility in> 350,000 cells derived from 13 mouse embryos at four …

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is crucial for profiling
histone modifications and transcription factor binding throughout the genome. However, its …

The first activation of gene expression during development (zygotic genome activation, ZGA)
is accompanied by massive changes in chromosome organization. The connection between …