Background Platelet transfusions are used to prevent and treat bleeding in people who are
thrombocytopenic. Despite improvements in donor screening and laboratory testing, a small …

Nowadays patients receiving blood components are exposed to much less transfusion-
transmitted infectious diseases than three decades before when among others HIV was …

Abstract The Practice Guidelines Committee of the American Society for Transplantation and
Cellular Therapy partnered with its Transplant Infectious Disease Special Interest Group to …

BACKGROUND: Emerging infections have been identified as a continuing threat to human
health. Many such infections are known to be transmissible by blood transfusion, while …

We report a transfusion trial of platelets photochemically treated for pathogen inactivation
using the synthetic psoralen amotosalen HCl. Patients with thrombocytopenia were …

Rapid chilling causes glycoprotein-Ib (GPIb) receptors to cluster on blood platelets. Hepatic
macrophage β2 integrin binding to β-N-acetylglucosamine (β-GlcNAc) residues in the …

Background: The transmission of pathogens via blood transfusion is still a major threat.
Expert conferences established the need for a pro-active approach and concluded that the …

Abstract Background Platelets (PLTs) are usually stored for up to 5 days prior to transfusion,
although in some blood services the storage period is extended to 7 days. During storage …

Pathogen reduction (PR) of platelet products increases costs and available clinical studies
are equivocal with respect to clinical and haemostatic effectiveness. We conducted a …

Thrombocytopenia is a frequent complication of viral infections providing evidence that
interaction of platelets with viruses is an important pathophysiological phenomenon. Multiple …