Toll-like receptor signaling and its role in cell-mediated immunity
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
The NLR gene family: from discovery to present day
The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …
genes that were later grouped into the family were already known at that time. Although it is …
Inflammasome activation and regulation: toward a better understanding of complex mechanisms
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets
V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
Tumor necrosis factor receptor-associated factor regulation of nuclear factor κB and mitogen-activated protein kinase pathways
Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally
related proteins that transduces signals from members of TNFR superfamily and various …
related proteins that transduces signals from members of TNFR superfamily and various …
Post-translational modification control of innate immunity
J Liu, C Qian, X Cao - Immunity, 2016 - cell.com
A coordinated balance between the positive and negative regulation of pattern-recognition
receptor (PRR)-initiated innate inflammatory responses is required to ensure the most …
receptor (PRR)-initiated innate inflammatory responses is required to ensure the most …
Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease
X Cao - Nature Reviews Immunology, 2016 - nature.com
In the initiation of innate immune responses against pathogens, pattern-recognition
receptors (PRRs) have an essential role in recognizing specific components of …
receptors (PRRs) have an essential role in recognizing specific components of …
A gut-vascular barrier controls the systemic dissemination of bacteria
In healthy individuals, the intestinal microbiota cannot access the liver, spleen, or other
peripheral tissues. Some pathogenic bacteria can reach these sites, however, and can …
peripheral tissues. Some pathogenic bacteria can reach these sites, however, and can …
NOD1 and NOD2 signalling links ER stress with inflammation
AM Keestra-Gounder, MX Byndloss, N Seyffert… - Nature, 2016 - nature.com
Endoplasmic reticulum (ER) stress is a major contributor to inflammatory diseases, such as
Crohn disease and type 2 diabetes,. ER stress induces the unfolded protein response …
Crohn disease and type 2 diabetes,. ER stress induces the unfolded protein response …