Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …

A single exposure to many viral and bacterial pathogens typically induces life-long immunity,
however, the development of the protective immunity to Plasmodium parasites is strikingly …

Humoral immunity consists of pre-existing antibodies expressed by long-lived plasma cells
and rapidly reactive memory B cells (MBC). Recent studies of MBC development and …

A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals
carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This …

IgG antibodies play a role in malaria immunity, but whether and how IgM protects from
malaria and the biology of Plasmodium falciparum (Pf)–specific IgM B cells is unclear. In a …

Long-lasting and sterile homologous protection against malaria can be achieved by the
exposure of malaria-naive volunteers under chemoprophylaxis to Plasmodium falciparum …

Clinical immunity to P. falciparum malaria is non‐sterilizing, with adults often experiencing
asymptomatic infection. Historically, asymptomatic malaria has been viewed as beneficial …

Passive transfer studies in humans clearly demonstrated the protective role of IgG
antibodies against malaria. Identifying the precise parasite antigens that mediate immunity is …

Abstract Background RTS, S/AS01, the leading malaria vaccine has been recommended by
the WHO for widespread immunization of children at risk. RTS, S/AS01-induced anti-CSP …

The Fulani ethnic group has relatively better protection from Plasmodium falciparum malaria,
as reflected by fewer symptomatic cases of malaria, lower infection rates, and lower parasite …