Chemotherapy agents used in the standard treatments for many types of cancer are
neurotoxic and can lead to lasting sensory and motor symptoms that compromise day-to-day …

Despite decades of research, we lack a mechanistic framework capable of predicting how
movement-related signals are transformed into the diversity of muscle spindle afferent firing …

Cancer survivors rank sensorimotor disability among the most distressing, long-term
consequences of chemotherapy. Disorders in gait, balance, and skilled movements are …

The axon initial segment (AIS) responsible for action potential initiation is a dynamic
structure that varies and changes together with neuronal excitability. Like other neuron …

Oxaliplatin (OX) chemotherapy can lead to long-term sensorimotor impairments in cancer
survivors. The impairments are often thought to be caused by OX-induced progressive …

Injury that severs peripheral nerves often results in long-lasting motor behavioral deficits and
in reorganization of related spinal motor circuitry, neither of which reverse even after nerve …

Persistent sensory, motor and cognitive disabilities comprise chemotherapy-induced neural
disorders (CIND) that limit quality of life with little therapeutic relief for cancer survivors. Our …

Background Oxaliplatin (OX) chemotherapy for colorectal cancer is associated with adverse
neurotoxic effects that can contribute to long-term sensorimotor impairments in cancer …

Background Dual-task function is compromised among individuals with prodromal
Alzheimer's disease (AD) and others at risk of developing AD. While exercise has been …

Muscle stiffness is altered following postmastectomy breast reconstruction and breast cancer
treatment. The exact mechanisms underlying these alterations are unknown; however …