Currently, obesity has become a global health issue and is referred to as an epidemic.
Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin …

Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin.
Insulin signaling is therefore critical for these tissues. However, decrease in insulin …

Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and
type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic …

Obesity is characterized by the deposition of excessive body fat, and is caused by energy
imbalance, especially when consuming fat-rich diets. High fat diet (HFD)-associated obesity …

Type 2 diabetes is caused by chronic insulin resistance and progressive decline in beta-cell
function. Optimal beta-cell function and mass is essential for glucose homeostasis and beta …

As age increases, the risk of developing type 2 diabetes increases, which is associated with
senile skeletal muscle dysfunction. During skeletal muscle aging, mitochondrial dysfunction …

Background Insulin resistance (IR) is one of the major hallmark for pathogenesis and
etiology of type 2 diabetes mellitus (T2DM). IR is directly interlinked with various …

Abstract Type 2 diabetes (T2D) is a complex multifactorial disease that emerges from the
combination of genetic and environmental factors, and obesity, lifestyle, and aging are the …

Oxidative stress (OS) has received extensive attention in the last two decades, because of
the discovery that abnormal oxidation status was related to patients with chronic diseases …