▪ Abstract The highly interconnected networks of the mammalian forebrain can generate a
wide variety of synchronized activities, including those underlying epileptic seizures, which …

Intractable seizures are just one manifestation of 'refractory epilepsy', which can be
recognized as a distinct condition with multifaceted dimensions, including neurobiochemical …

Objective Conventional anticonvulsants reduce neuronal excitability through effects on ion
channels and synaptic function. Anticonvulsant mechanisms of the ketogenic diet remain …

Epilepsy encompasses a diverse group of seizure disorders caused by a variety of
structural, cellular and molecular alterations of the brain primarily affecting the cerebral …

Neurocysticercosis is a leading cause of seizures and epilepsy in the developing world and
is an increasingly important health issue in the United States. Recent results from the …

Symptomatic temporal lobe epilepsy typically develops in three phases: brain insult→
latency period (epileptogenesis)→ recurrent seizures (epilepsy). We hypothesized that …

The authors propose that epilepsy research embark on a revitalized effort to move from
targeting control of symptoms to strategies for prevention and cure. The recent advances that …

It has been proposed that the underlying epileptic process is mediated by changes in both
excitatory and inhibitory circuits leading to the formation of hyper-excitable seizure networks …

No other epilepsy more substantially combines cryptogenicity and intractability than does
Lennox‐Gastaut Syndrome. Although antecedent neurological conditions have preceeded …

Human mesial temporal lobe epilepsies (MTLE) are the most frequent form of partial
epilepsies and display frequent pharmacoresistance. The molecular alterations underlying …