In recent years, protein arginine methyltransferases (PRMTs) have emerged as new
members of a gene expression regulator family in eukaryotes, and are associated with …

The main localization of nucleolin is the nucleolus, but this protein is present in multiple
subcellular sites, and it is unconventionally secreted. On the cell surface, nucleolin acts as a …

Background: Since primary prostate cancer (PCa) can advance to the life-threatening
metastatic PCa, exploring the molecular mechanisms underlying PCa metastasis is crucial …

Osteoclasts are the exclusive bone-resorbing cells, playing a central role in bone
metabolism, as well as the bone damage that occurs under pathological conditions,. In …

Polarization status of tumor-associated macrophages (TAMs) plays an essential role in
tumor growth and invasion. However, emerging treatment like photothermal therapy (PTT) …

Tumor metastasis is the leading cause of mortality among advanced cancer patients.
Understanding its mechanisms and treatment strategies is vital for clinical application …

Cancer, one of the most mortal diseases worldwide, is characterized by the gain of specific
features and cellular heterogeneity. Clonal evolution is an established theory to explain …

Objectives It is imperative to develop efficient strategies on the treatment of prostate cancer.
Here, we constructed multifunctional nanoparticles, namely AS1411@ MPDA‐DTX (AMD) …

Abstract Protein arginine methyltransferase 5 (PRMT5) was discovered two decades ago.
The first decade focused on the biochemical characterization of PRMT5 as a regulator of …

Background PRMT5 is a type II protein arginine methyltransferase that methylates histone or
non-histone proteins. Arginine methylation by PRMT5 has been implicated in gene …