A materials roadmap to functional neural interface design

SM Wellman, JR Eles, KA Ludwig… - Advanced functional …, 2018 - Wiley Online Library
Advancements in neurotechnologies for electrophysiology, neurochemical sensing,
neuromodulation, and optogenetics are revolutionizing scientific understanding of the brain …

Human mini-brain models

HY Tan, H Cho, LP Lee - Nature biomedical engineering, 2021 - nature.com
Engineered human mini-brains, made possible by knowledge from the convergence of
precision microengineering and cell biology, permit systematic studies of complex …

Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium

G Seano, HT Nia, KE Emblem, M Datta, J Ren… - Nature biomedical …, 2019 - nature.com
The compression of brain tissue by a tumour mass is believed to be a major cause of the
clinical symptoms seen in patients with brain cancer. However, the biological consequences …

Towards brain-tissue-like biomaterials

E Axpe, G Orive, K Franze, EA Appel - Nature Communications, 2020 - nature.com
Many biomaterials have been developed which aim to match the elastic modulus of the
brain for improved interfacing. However, other properties such as ultimate toughness, tensile …

Rheological characterization of human brain tissue

S Budday, G Sommer, J Haybaeck, P Steinmann… - Acta biomaterialia, 2017 - Elsevier
The rheology of ultrasoft materials like the human brain is highly sensitive to regional and
temporal variations and to the type of loading. While recent experiments have shaped our …

Cavitation in soft matter

CW Barney, CE Dougan, KR McLeod… - Proceedings of the …, 2020 - National Acad Sciences
Cavitation is the sudden, unstable expansion of a void or bubble within a liquid or solid
subjected to a negative hydrostatic stress. Cavitation rheology is a field emerging from the …

The overlooked aspect of excitotoxicity: Glutamate‐independent excitotoxicity in traumatic brain injuries

J Tehse, C Taghibiglou - European journal of neuroscience, 2019 - Wiley Online Library
Traumatic brain injury (TBI) is a leading major cause of morbidity and mortality in youth and
individuals under 45 year age. A wide variety of cellular and molecular mechanisms have …

Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface

NJ Michelson, AL Vazquez, JR Eles… - Journal of neural …, 2018 - iopscience.iop.org
Objective. Implantable neural electrode devices are important tools for neuroscience
research and have an increasing range of clinical applications. However, the intricacies of …

[HTML][HTML] Mechanosensation in traumatic brain injury

CE Keating, DK Cullen - Neurobiology of disease, 2021 - Elsevier
Traumatic brain injury (TBI) is distinct from other neurological disorders because it is
induced by a discrete event that applies extreme mechanical forces to the brain. This review …

Instantaneous whole-brain strain estimation in dynamic head impact

K Ghazi, S Wu, W Zhao, S Ji - Journal of Neurotrauma, 2021 - liebertpub.com
Head injury models are notoriously time consuming and resource demanding in simulations,
which prevents routine application. Here, we extend a convolutional neural network (CNN) …