Unilateral ureteric obstruction (UUO) is one of the most commonly applied rodent models to
study the pathophysiology of renal fibrosis. This model reflects important aspects of …

Adaptive homeostasis is defined as the transient expansion or contraction of the
homeostatic range following exposure to subtoxic, non-damaging, signaling molecules or …

Cytoglobin (Cygb), a novel member of the globin superfamily, is expressed by fibroblasts in
various organs. However, its function remains unknown. Because of its localization, we …

Noninvasive diagnosis of atherosclerosis via single biomarkers has been attempted but
remains elusive. However, a previous polymarker or pattern approach of urine polypeptides …

To gain molecular insight into kidney function, we performed a high-resolution quantitative
analysis of gene expression in glomeruli and nine different nephron segments dissected …

Hypertension is the most prevalent cause of cardiovascular disease and kidney failure, but
only about 50% of patients achieve adequate blood pressure control, in part, due to inter …

Increased levels of a soluble form of endoglin (sEng) circulating in plasma have been
detected in various pathological conditions related to cardiovascular system. High …

Gender differences in the incidence and severity of hypertension have suggested the
involvement of a sex-dependent mechanism. Transgenic (Tg) mice overexpressing kidney …

Sesamin, the major lignan found in sesame, has been shown to increase vitamin E levels by
inhibiting its metabolism via the cytochrome P450 isozyme CYP4F2. CYP4F2 and CYP4A11 …

Fabry disease is caused by deficient activity of α-galactosidase A and subsequent
accumulation of glycosphingolipids (mainly globotriaosylceramide, Gb3), leading to …